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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor ALAM,MAHMOOD (1) CAI,LIN (1) Chen,S.C. (1) Cui,D.D. (1) Huang,Y. (1) Ji,L.L. (1) LUTHER T.,CLARK (1) Mao,S.H. (1) Qiu,M. (1) RAHMAN,ASIM (1) RAO,SUDHA (1) SHAFIQ,SAYID (1) SIDDIQUI,M.A.Q (1) Yi,C. (1) Mais... Palavra-chave Adriamycin (2) Apoptosis (1) Atrial natriuretic peptide (1) Breast cancer (1) Gene expression (1) Heart failure (1) Synergism (1) TRAIL (1) TRAIL receptors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2009 (1) 2001 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Differential effects of doxorubicin on atrial natriuretic peptide expression in vivo and in vitro Biol. Res. RAHMAN,ASIM; ALAM,MAHMOOD; RAO,SUDHA; CAI,LIN; LUTHER T.,CLARK; SHAFIQ,SAYID; SIDDIQUI,M.A.Q. Doxorubicin (Dox) is a potent anti-cancer agent with cardiotoxic side-effects but the mechanism of its cardiotoxicity and its effect on expression of the vasoactive atrial natriuretic peptide (ANP), an important marker for cardiac hypertrophy, are little understood. The present study examined Dox-induced changes in vivo in hearts of 6 mongrel dogs and 5 Sprague-Dawley rats and in vitro in cardiac cultures of neonatal rats. Quantitative RT-PCR analysis using g32-p labeled primers for ß-actin, phospholamban (PLB) and ANP showed a selective 5-fold increase of ANP mRNA in Dox-treated dog hearts in comparison to controls. Similarly, northern analysis of GAPD, ß-actin, cardiac a-actin and ANP gave a selective 4.5-fold increase in ANP transcripts in Dox-treated... Tipo: Journal article Palavras-chave: Atrial natriuretic peptide; Gene expression; Adriamycin; Heart failure. Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300007 Synergistic antitumor effect of TRAIL and adriamycin on the human breast cancer cell line MCF-7 BJMBR Cui,D.D.; Huang,Y.; Mao,S.H.; Chen,S.C.; Qiu,M.; Ji,L.L.; Yi,C.. The aim of the present study was to determine the effect of the combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and adriamycin (ADM) on the human breast cancer cell line MCF-7 and to identify potential mechanisms of apoptosis. Cell viability was analyzed by the MTT assay and the synergistic effect was assessed by the Webb coefficient. Apoptosis was quantified using the annexin V-FITC and propidium iodide staining flow cytometry. The mRNA expression of TRAIL receptors was measured by RT-PCR. Changes in the quantities of Bax and caspase-9 proteins were determined by Western blot. MCF-7 cells were relatively resistant to TRAIL (IC50 >10 µg/mL), while MCF-7 cells were sensitive to ADM (IC50 <10 µg/mL). A subtoxic... Tipo: Info:eu-repo/semantics/article Palavras-chave: TRAIL; TRAIL receptors; Breast cancer; Adriamycin; Apoptosis; Synergism. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900013 Registros recuperados: 2 Primeira ... 1 ... Última

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