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Racial inequalities in the socioeconomic, demographic and health conditions of elderly from Maranhão State, Legal Amazon, Brazil: a population-based study Acta Amazonica
Oliveira,Bruno Luciano Carneiro Alves de; Silva,Alécia Maria da; Silva,Raimundo Antonio da; Thomaz,Erika Barbara Abreu Fonseca.
Aging with quality of life does not occur equally among the racial groups of Brazilian elderly, and few studies have analyzed this issue in the states of the Brazilian Legal Amazon. The objective of this study was to investigate racial inequalities in the socioeconomic, demographic and health conditions of elderly residents of Maranhão state, Brazil. The present work is a cross-sectional study of 450 elders aged 60 years or older included in the 2008 National Household Sample Survey. The prevalence of socioeconomic, demographic, health and habit indicators and of risk factors were estimated in white, brown and black racial categories that were self-reported by the survey participants. The chi-square test was used for comparisons (a=5%). The majority of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Social inequity; Epidemiology; Indicators; Race or ethnic group distribution.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000300006
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Blood pressure, heart rate and its autonomic modulation in malnourished rats at different ages Biological Sciences
Sant’Helena, Bruna da Rosa Maggi; Brasileiro-Santos, Maria do Socorro; Falcão, Elis Pereira; Duarte, Denia Palmeira Fittipaldi; Pontes Filho, Nicodemos Telles de; Costa, Carlos Peres da.
Malnutrition is responsible for a number of alterations that occur in the organism, including alterations in the cardiovascular system. We hypothesize that long periods of malnutrition occurring after weaning may also be responsible for alterations in the cardiovascular system. Wistar rats were separated into the two following experimental groups: a labina® diet-fed control group (CG) and a malnourished group (MG), fed a multi-deficient diet. Results showed that the mg presented significantly lower body weight (p < 0.001) in rats of all ages, higher heart rate (HR) (p < 0.05) when rats were 3, 4 and 5 months old and lower HR in rats from 6 to 9 months of age, in relation to the CG. Spectral analysis showed a significant increase in the low...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.07.00.00-8; Aging; Multi-deficient diet; Eletrocardiography; Spectral analysis morphology of the ventricles Fisiologa.
Ano: 2014 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/21482
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STORING, DISTRIBUTION AND BLENDING OF BIODIESEL CIGR Journal
Micic, Radoslav.
Due to nature of biodiesel fuel (B100) as well as biodiesel and fossil diesel oil blends these fuels demands specific conditions of storage, handling, transportation and distribution. Although it is necessary to pay attention to each of the elements in the distribution chain, the most critical operations are related to storing. Tanks for biodiesel storinghave a dominant influence on the maintenance of stable quality, as may occur, issues that directly affect the degradation in quality and problems during distribution, blending and use. In the designing process of the tank space and the installations must be taken into account all specificities of biodiesel also that materials are resistant to the influence of biodiesel and does not affect it contamination....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Transesterification of fatty acid methyl esters (FAME); Aging; Storing; Blending.
Ano: 2020 URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/5583
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Immune System Dysfunction in the Elderly Anais da ABC (AABC)
FUENTES,EDUARDO; FUENTES,MANUEL; ALARCÓN,MARCELO; PALOMO,IVÁN.
ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Immunosenescence; Adaptive immunity; Innate immunity; Inflammation..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285
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Administering ascorbic acid to rats undergoing ageing processes: effects on myosin-V immunoreactive myenteric neurons Anais da ABC (AABC)
Mello,Sônia A.; Marese,Angélica C.M.; Brancalhão,Rose M.C.; Zanoni,Jacqueline N.; Natali,Maria Raquel M..
During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse the behaviour of morphoquantative myenteric neurons in the duodenum of adult Wistar rats with aged 90 (C90), 345 (E345) and 428 (E428) days, as well as animals of the same age who received ascorbic acid supplementation for 120 days (EA345 and EA428). Whole-mount preparations of muscle layer from the duodenum of the animals were immunostained by the method myosin V. 80 microscopic fields were quantified (14.8 mm2/animal) and measured 100...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Antioxidant; Enteric nervous system; Immunohistochemistry.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100337
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Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats Anais da ABC (AABC)
PEREIRA,JOICE N.B.; MARI,RENATA B.; STABILLE,SANDRA R.; FARIA,HAROLDO G. DE; MOTA,THAIS F.M.; FERREIRA,WALTER M..
Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive function. Caloric restriction has been used in several studies with the intention of delaying deleterious effects of aging. This study aimed to evaluate the effects of caloric restriction on myenteric neurons of ileum by aging in rats. 30 Wistar rats were grouped as follows: GI (animals aged 6 months fed with normal diet), GII (animals aged 18 months fed with normal diet) and GIII (animals aged 18 months subject to 31% of caloric restriction)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Caloric restriction; Myenteric plexus; Small intestine.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301471
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Response of the brain to enrichment Anais da ABC (AABC)
DIAMOND,MARIAN C..
Before 1960, the brain was considered by scientists to be immutable, subject only to genetic control. In the early sixties, however, investigators were seriously speculating that environmental influences might be capable of altering brain structure. By 1964, two research laboratories proved that the morphology and chemistry or physiology of the brain could be experientially altered (Bennett et al. 1964, Hubel and Wiesel 1965). Since then, the capacity of the brain to respond to environmental input, specifically "enrichment,'' has become an accepted fact among neuroscientists, educators and others. In fact, the demonstration that environmental enrichment can modify structural components of the rat brain at any age altered prevailing presumptions about the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enrichment; Cerebral cortex; Hippocampus; Aging; Adult neurogenesis; Dendrites.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000200006
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Histological evaluation of the periodontal ligament from aged wistar rats supplemented with ascorbic acid Anais da ABC (AABC)
Zanoni,Jacqueline N.; Lucas,Nathalia M.; Trevizan,Aline R.; Souza,Ivan D.S..
Ascorbic acid (AA) is able to neutralize reactive oxygen species and is essential for collagen synthesis. In aging process oxidative stress is elevated. This study aims to investigate the effects of AA supplementation on the periodontal ligament (PL) of rats during aging. Twenty five rats were used and divided into groups: J90 (90-day-old control), E345 (345-day-old control), E428 (428-day-old control), EA345 (345-day-old supplemented with AA from 90-day-old on) and EA428 (428-day-old supplemented with AA from 90-day-old on). We analyzed the thickness, density of fibroblasts and blood vessels and collagen fibers types in the PL. In group J90 there was predominantly type III collagen fibers (87.64%). In animals supplemented with AA, the area filled by type...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Ascorbic acid; Collagen; Periodontal ligament.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100327
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Age related interaction of dopamine and serotonin synthesis in striatal synaptosomes Biocell
Messripour,Manoochehr; Mesripour,Azadeh.
Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosyn-thesis of dopamine and serotonin, respectively. Since both enzymes are active in striatum, and affected by age, this study was undertaken to investigate interaction between dopamine and serotonin synthesis in brain striatal synaptosomes of aging rat. Male Wistar rats (3 and 30 month old) were killed by decapitation and brain striatal synaptosomes were prepared by discontinuous Ficoll/sucrose gradient technique. Synaptosomes were incubated in the presence of added pargiline (monoamineoxidase inhibitor), dopamine or serotonin synthesized during 25 min was measured by HPLC, employing electrochemical detection. Dopamine synthesis in synaptosomes prepared from young...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Nerve ending; Neurotransmitter; Tyrosine hydroxylase; Tryptophan hydroxylase.
Ano: 2013 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452013000200001
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Effect of age on the myosin-V immunoreactive myenteric neurons of rats ileum Biocell
Ferreira Schoffen,João Paulo; Marçal Natali,Maria Raquel.
Alterations in the gastrointestinal neuromuscular function related to age have been demonstrated in human and animal models. This study analyzes the effects of the aging process on the area of the neuronal cell bodies of the myenteric plexus in the antimesenteric and intermediate regions of the ileal circumference of Wistar, 12 month-old in comparison 3 month-old animals. The ileum was removed and whole-mount preparations immunostained by the antibody anti-myosin-V were processed. The morphometric analyses were performed using a computerized image analysis system, with a subsequent distribution of neurons by size in intervals of 100 &#956;m². The cellular body morphometry revealed a significant increase in the size of the myosin-V- immunoreactive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Ileum; Myenteric plexus; Myosin-V; Neuronal plasticity.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000100004
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Histomorphological and quantitative immunohistochemical changes in the rat pancreas during aging Biocell
Riccillo,F.L.; Bracamonte,M.I.; Cónsole,G.M.; Gómez Dumm,C.L.A..
Although the endocrine pancreas is the purpose of several deep investigations, morphological data referred to the effect of aging on the gland are not homogeneous. The purpose of the current work was to analyze the changes occurring in the pancreas of aged rats, with especial reference to the islet cell populations. Six young (Y), old (O) and senescent (S) male Sprague-Dawley rats were used. The pancreas tails were processed for light microscopy and studied by means of routine stains as well as by immunohistochemical identification of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide- secreting cells (Dako Envision System, DAB as chromogen). A progressive pancreatic histoarchitecture distortion was found among the aged animals. Even when the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Pancreas; Islets; Immunohistochemistry; Morphometry.
Ano: 2004 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000200001
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Free radical chemistry in biological systems Biol. Res.
VALDEZ,LAURA B; LORES ARNAIZ,SILVIA; BUSTAMANTE,JUANITA; ALVAREZ,SILVIA; COSTA,LIDIA E; BOVERIS,ALBERTO.
Mitochondria are an active source of the free radical superoxide (O2-) and nitric oxide (NO), whose production accounts for about 2% and 0.5% respectively, of mitochondrial O2 uptake under physiological conditions. Superoxide is produced by the auto-oxidation of the semiquinones of ubiquinol and the NADH dehydrogenase flavin and NO by the enzymatic action of the nitric oxide synthase of the inner mitochondrial membrane (mtNOS). Nitric oxide reversibly inhibits cytochrome oxidase activity in competition with O2. The balance between NO production and its utilization results in a NO intramitochondrial steady-state concentration of 20-50 nM, which regulates mitochondrial O2 uptake and energy supply. The regulation of cellular respiration and energy production...
Tipo: Journal article Palavras-chave: Superoxide radical; Nitric oxide; Peroxynitrite; Mitochondria; Apoptosis; Aging.
Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200005
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Superoxide dismutase and catalase: tissue activities and relation with age in the long-lived species Margaritifera margaritifera Biol. Res.
FERNÁNDEZ,CARLOS; SAN MIGUEL,EDUARDO; FERNÁNDEZ-BRIERA,ALMUDENA.
Free radicals are extremely reactive and produce damage and modify cell functions. Furthermore, superoxide dismutase and catalase are believed to play a key role in the enzymatic defence of the cells. Indeed, some authors have argued that reduced free-radical damage could explain increased longevity. Margaritifera margaritifera is one of the longest-lived animals in the world (up to 100-200 years). Furthermore, this organism may serve as a useful model for gerontologists interested in exploring the mechanisms that promote long life and the slowing of senescence. The present study estimated for the first time individual enzymatic activity for superoxide dismutase isozymes (Cu,Zn-SOD and Mn-SOD) and catalase in tissue preparations of gills, digestive glands...
Tipo: Journal article Palavras-chave: Margaritifera margaritifera; Free radicals; Aging; Superoxide dismutase; Catalase.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100006
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On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae) Biol. Res.
Rivera,Daniela S.; Inestrosa,Nibaldo C.; Bozinovic,Francisco.
Cognitive ecologist posits that the more efficiently an animal uses information from the biotic and abiotic environment, the more adaptive are its cognitive abilities. Nevertheless, this approach does not test for natural neurodegenerative processes under field or experimental conditions, which may recover animals information processing and decision making and may explain, mechanistically, maladaptive behaviors. Here, we call for integrative approaches to explain the relationship between ultimate and proximate mechanisms behind social behavior. We highlight the importance of using the endemic caviomorph rodent Octodon degus as a valuable natural model for mechanistic studies of social behavior and to explain how physical environments can shape social...
Tipo: Journal article Palavras-chave: Cognitive ecology; Octodon degus; Social behavior; Stress; Aging; Alzheimer's disease.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100010
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Long lasting structural changes in primary motor cortex after motor skill learning: a behavioural and stereological study Biol. Res.
MORALES,PAOLA.
Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled reaching task). Rats were trained a lateralised reaching task during an "early" (22-31 days oíd) or "late" (362-371 days oíd) postnatal period. The trained and corresponding control rats were sacrificed at day 372, immediately after the behavioural testing. The "early" trained group preserved the learned skilled reaching task when tested at day 372, without requiring any additional training. The "late" trained group showed a similar capacity to...
Tipo: Journal article Palavras-chave: Motor cortex; Plasticity; Persistence of structural changes; Aging; Motor skill learning (skilled reaching task); Stereology; Rat.
Ano: 2008 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000400005
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Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans Biol. Res.
Park,Seul-Ki; Park,Sang-Kyu.
Electrolyzed-reduced water (ERW) scavenges reactive oxygen species and is a powerful anti-oxidant. A positive correlation between oxidative stress and aging has been proved in many model organisms. In Caenorhabditis elegans, many long-lived mutants showed reduced fertility as a trade off against longevity phenotype. We aimed to study the effect of ERW on oxidative stress, fertility and lifespan of C. elegans. We also investigated the genetic pathway involved in the effect of ERW on resistance to oxidative stress and lifespan. We compared lifespan and fertility of worms in media prepared with distilled water and ERW. ERW significantly extended lifespan and increased the number of progeny produced. Then the effect of ERW on resistance to oxidative stress and...
Tipo: Journal article Palavras-chave: Electrolyzed-reduced water; Aging; Daf-16; Fertility; Lifespan.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200005
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T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells Biol. Res.
LEIVA-SALCEDO,ELIAS; PEREZ,VIVIANA; ACUÑA-CASTILLO,CLAUDIO; WALTER,ROBIN; SIERRA,FELIPE.
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as inhibition of the ERK signaling pathway. T-kininogen is a potent inhibitor of cysteine proteinases, and we have described that the inhibition of ERK activity occurs, at least in part, via stabilization of the MAP kinase phosphatase, MKP-1. Since fibroblasts are not a physiological target of T-kininogen, we have now purified the protein from rat serum, and used it to assess the effect of T-kininogen on endothelial cells. Adding purified T-kininogen to EAhy 926 hybridoma cells resulted in inhibition of basal ERK activity levels, as estimated...
Tipo: Journal article Palavras-chave: Aging; Endothelial cells; ERK pathway; Kininogen; Kinins.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200020
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Age-related Changes in DNA Methylation Status of hTERT Gene Promoter of Oral Epithelial Cells BABT
Bezerra,Stephane Flaviane de Oliveira; Costa,Ludimila de Araújo; Freitas,Priscylla Alves Nascimento de; Oliveira,Naila Francis Paulo de.
The purpose of this study was to investigate the effect of aging on the DNA methylation status of two genes involved in tumorigenesis (telomerase gene hTERT and DNA repair gene- MLH1) and one in metabolism (methylenetetrahydrofolate reductase gene- MTHFR) in oral epithelial cells. DNA methylation analysis was performed by Methylation Sensitive Restriction Enzymes (MSRE) of healthy oral epithelial cells of child (6-10 years, n=21), young (20-25 years, n=19) and elderly (over 60 years, n=25). The results for the hTERT gene showed significant variation in the methylation frequency at CpG dinucleotides among the groups (p=0.0001), with the methylated condition more frequently in children and young people. In relation to MLH1 and MTHFR, no differences were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epigenetic; DNA methylation; Aging; DNA repair; Telomerase; MTHFR.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100082
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Cellular aging: theories and technological influence BABT
Mercado-Sáenz,Silvia; Ruiz-Gómez,Miguel J.; Morales-Moreno,Francisco; Martínez-Morillo,Manuel.
The aim of this article was to review the factors that influence the aging, relationship of aging with the biological rhythms and new technologies as well as the main theories to explain the aging, and to analysis the causes of aging. The theories to explain the aging could be put into two groups: those based on a program that controlled the regression of the organism and those that postulated that the deterioration was due to mutations. It was concluded that aging was a multifactorial process. Genetic factors indicated the maximum longevity of the individual and environmental factors responsible for the real longevity of the individual. It would be necessary to guarantee from early age the conservation of a natural life rhythm.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Longevity; Biological rhythms; Caloric restriction; Telomerase; Free radical.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600008
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Diet, Epidemiological Factors and Cognitive Impairment: A Cross-Sectional Study in the Elderly Population BABT
França,Vivian Francielle; Azzolini,Thairine; Pissaia,Ediane; Bortoloti,Durcelina Schiavoni; Signorini,Taise; Costa,Lediana Dalla; Souza,Marília Moraes Queiroz; Lívero,Francislaine Aparecida dos Reis; Lovato,Evellyn Claudia Wietzikoski.
ABSTRACT Purpose Population aging is one of the great achievements of humanity. However, with aging, the incidence of chronic diseases and those related to cognition deficits increase. In this way, strategies aimed at preventing or delaying cognitive deficit are extremely necessary. Thus, this study investigates the relationship between cognitive deficits, schooling and eating habits in a Brazilian elderly population. Methods The dietary habits of 400 older adults were investigated through structured questionnaires. Unhealthy eating habits such as low consumption of fruits, vegetables and beans, consumption of fatty meats and whole milk, adjusted for other variables, were evaluated. Cognitive function was assessed by the Mini Mental State Examination...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Cognitive; Diet; Fruits; Schooling; Vegetable.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100327
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