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| Lou,Zhaohuan; Wang,Junwei; Chen,Yingjun; Xu,Chandi; Chen,Xinyi; Shao,Tiejuan; Zhang,Kena; Pan,Hongying. |
| This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB) pathway. ALD rat models were established by intragastric liquor [50% (v/v) ethanol] administration at 10 mL/kg body weight for 20 days. Rats were divided into six groups: normal group (no treatment), model group (ALD rats), Essentiale group (ALD rats fed with Essentiale, 137 mg/kg), and LREE high/moderate/low dose groups (ALD rats fed with 4, 2, or 1 g LREE/kg). NF-κB and LPS levels were evaluated. Liver pathological changes and intestinal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lindera aggregata (Sims) Kosterm; Ethanol extract; Alcoholic liver disease; Intestinal endotoxemia; 16S ribosomal RNA gene sequencing; Tight junction protein. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600601 |
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| Maimaitimin,Kuerbanjiang; Jiang,Zhihui; Aierken,Aili; Shayibuzhati,Mikeremu; Zhang,Xiaoying. |
| Overconsumption of alcohol leads to alcoholic liver disease (ALD). Natural compounds have been investigated previously for their hepatoprotective activities against liver injury. This study investigated the protective effect of Alhagi sparsifolia on ALD. Alcohol was administered to mice for three consecutive days; either alone or in combination with Alhagi sparsifolia extract (150, 300, 600 mg/kg). Serum aspartate aminotransferase and alanine transaminase as biomarkers of liver injury, the content of malonaldehyde, hydrogen peroxide (H2O2) and glutathione which indicated the redox status of liver and the antioxidant enzyme activity of super oxide dismutase were detected, respectively. Moreover, the expression of protein cytochrome P450 2E1 (CYP2E1) the key... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alcoholic liver disease; Alhagi sparsifolia; Hepatoprotective effect; Antioxidantion; CYP2E1. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300625 |
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