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| PELAYO,HELVIA R; PINCHEIRA,JUANA; GIMÉNEZ-ABIÁN,JUAN F; CLARKE,DUNCAN J; DE LA TORRE,CONSUELO. |
| Allium cepa L. meristems were used as a plant model to study the p53-independent control of S and G2 phases by checkpoint pathways, in eukaryotic cells. Checkpoint blocks were induced at early and mid S by hydroxyurea. After their spontaneous override, cells became accumulated in G2-prophase, giving rise later on to a delayed mitotic wave. Cell growth was maintained during the checkpoint blocks, as the delayed mitoses were larger in size than the control ones. Under continuous hydroxyurea treatment, the delayed mitotic was formed by two subpopulations: normal mitoses corresponding to cells having properly recovered from the checkpoint block, and abnormal ones resulting from checkpoint adaptation. These latter cells displayed broken chromatids as they had... |
| Tipo: Journal article |
Palavras-chave: Checkpoint adaptation; Hydroxyurea; S and G2 checkpoints; P53-independent checkpoints; Allium cepa L. meristems. |
| Ano: 2003 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300009 |
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