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Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1 BABT
Leite,Elza Regina Manzolli; Lima,Oswaldo Luiz Luz; Leite,Fábio Renato Manzolli; Costa,Paulo Inácio da.
The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The presence of class I anti-HLA alloantibodies and HLA allele's were determined. Clinical evolution was set as fast (<1 year between diagnostic and death), moderate (1-3 years) or slow (>3 years). Class I anti-HLA alloantibodies presence was lower in healthy individuals than in those infected by HIV-1 (4.2% against 32.4%). However, an equal distribution of these alloantibodies was found among the individuals infected, independent on the clinical evolution. Thus,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS; HIV; HLA antigens; Alloantibodies.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100012
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