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	Provedor de dados Electron. J. Biotechnol. (1) Genet. Mol. Biol. (1) Autor Chibani,Jemni Ben (1) Denden,Sabri (1) Ghadicholaei,Kamran Khalili (1) Hasannia,Sadegh (1) Hayek,Donia (1) Khelil,Amel Haj (1) Knani,Jalel (1) Leban,Nadia (1) Pirooznia,Nazanin (1) Sangachini,Elham Dasi (1) Taghdir,Majid (1) Mais... Palavra-chave Alpha1-antitrypsin (2) Computational analysis (1) Damaging mutation (1) Molecular dynamic simulation (1) Pichia pastoris (1) Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2012 (1) 2010 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Construction of an engineered alpha 1-antitrypsin with inhibitory activity based on theoretical studies Electron. J. Biotechnol. Sangachini,Elham Dasi; Hasannia,Sadegh; Taghdir,Majid; Pirooznia,Nazanin; Ghadicholaei,Kamran Khalili. Background: The elastase inhibitor α-1-antitrypsin (AAT), is a member of the serpin superfamily of protease inhibitors. AAT has a characteristic secondary structure of three-β-sheets, nine-α-helices and a reactive central loop (RCL). This protein inhibits target proteases by forming a stable complex in which the cleaved RCL is inserted into β-sheet-A of the serpin, leading to a conformational change in the AAT protein. Spontaneous polymerization and instability of AAT are challenges with regard to producing drugs against AAT-deficient diseases. Therefore, the purpose of many investigations currently is to produce drugs with lower degrees of polymerization and higher stabilities. In order to investigate the effect of the... Tipo: Journal article Palavras-chave: Alpha1-antitrypsin; Molecular dynamic simulation; Pichia pastoris. Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000200008 In silico analysis of alpha1-antitrypsin variants: the effects of a novel mutation Genet. Mol. Biol. Denden,Sabri; Leban,Nadia; Hayek,Donia; Knani,Jalel; Chibani,Jemni Ben; Khelil,Amel Haj. Alpha1-antitrypsin (AAT) is a highly polymorphic protein with more than 120 variants that are classified as normal (normal protein secretion), deficient (reduced circulating AAT level caused by defective secretion) or null (no protein secretion). Alpha1-antitrypsin deficiency, one of the most common genetic disorders, predisposes adults to pulmonary emphysema and, to a lesser extent, chronic liver disease and cirrhosis. In this report, we provide additional sequence data for alpha1-antitrypsin based on the characterization of a novel variant detected in a 53-year-old heterozygous patient with chronic obstructive pulmonary disease. The mutation occurred on a PI*M2 base allele and was characterized by a T → C transition at nt 97 in exon II that led to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alpha1-antitrypsin; Computational analysis; Damaging mutation. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400006 Registros recuperados: 2 Primeira ... 1 ... Última

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