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| Dolabela,M.F.; Pereira,M.T.; Salas,C.E.; Steffani,G.M.; Nelson,D.L.; Piló-Veloso,D.; Lopes,M.T.P.. |
| We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co <FONT FACE="Symbol">g</FONT>-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Aminothiols; Cytotoxic effect; Radioprotector; Antitumorigenic effect. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000800010 |
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