|
|
|
|
|
| Çelebier,Mustafa; Kaynak,Mustafa Sinan; Altınöz,Sacide; Sahin,Selma. |
| A simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C18 column (ODS 2, 10 μm, 200 x 4.6 mm) and a mobile phase of phosphate buffer (pH 3.6 , 0.01 mol L-1):acetonitrile: methanol (46:44:10 v/v/v) mixture were used for separation and quantification. Analyses were run at a flow-rate of 1 mL min-1 and at ambient temperature. The injection volume was 20 μL and the ultraviolet detector was set at 240 nm. Under these conditions, amlodipine and valsartan were eluted at 7.1 min and 3.4 min, respectively. Total run time was shorter than 9 min. The developed method was validated according to the literature and found to be linear... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amlodipine besylate; Valsartan; High Performance Liquid Chromatography; Method Development; Validation; Dissolution Study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400018 |
| |
|
| |
|
|
|
