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| Assumpção,Paulo Pimentel de; Seabra,Aline Damasceno; Leal,Mariana Ferreira; Guimarães,Adriana Costa; Calcagno,Danielle Queiroz; Khayat,André Salim; Smith,Marilia de Arruda Cardoso; Burbano,Rommel Rodriguez. |
| In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumor cells that allows the increase of mutations is named genetic instability, encompassing two mechanisms: microsatellite instability, characterized by nucleotide alterations with errors in the DNA repair systems; and chromosomal instability, represented by aberrations occurring in large chromosome segments. Carcinomas are characterized by complex cytogenetic alterations and large gene amalgamations. Telomeric alterations, inadequately repaired DNA breaks, and... |
| Tipo: Journal article |
Palavras-chave: Chromosomal instability; Carcinomas; Aneuploidies. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400007 |
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