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	Provedor de dados BJMBR (1) Autor Benseñor,I. (1) Krieger,J.E. (1) Lotufo,P.A. (1) Mota,G.A. (1) Pereira,A.C. (1) Palavra-chave ACE (1) Angiotensin-converting enzyme (1) Angiotensinogen (1) Association study (1) Genetics (1) Hypertension (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies BJMBR Pereira,A.C.; Mota,G.A.; Benseñor,I.; Lotufo,P.A.; Krieger,J.E.. Previous genetic association studies have overlooked the potential for biased results when analyzing different population structures in ethnically diverse populations. The purpose of the present study was to quantify this bias in two-locus association studies conducted on an admixtured urban population. We studied the genetic structure distribution of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen methionine/threonine (M/T) polymorphisms in 382 subjects from three subgroups in a highly admixtured urban population. Group I included 150 white subjects; group II, 142 mulatto subjects, and group III, 90 black subjects. We conducted sample size simulation studies using these data in different genetic models of gene action and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Association study; Genetics; Angiotensin-converting enzyme; ACE; Angiotensinogen. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100008 Registros recuperados: 1 Primeira ... 1 ... Última

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