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| Registros recuperados: 34 | |
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| Le Roux, Frederique; Wegner, K. Mathias; Baker-austin, Craig; Vezzulli, Luigi; Osorio, Carlos R.; Amaro, Carmen; Ritchie, Jennifer M.; Defoirdt, Tom; Destoumieux-garzon, Delphine; Blokesch, Melanie; Mazel, Didier; Jacq, Annick; Cava, Felipe; Gram, Lone; Wendling, Carolin C.; Strauch, Eckhard; Kirschner, Alexander; Huehn, Stephan. |
| Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring during episodes of unusually warm weather. Similar patterns were also observed in Vibrio-associated diseases affecting marine organisms such as fish, bivalves and corals. Basic knowledge is still lacking on the ecology and evolutionary biology of these bacteria as well as on their virulence mechanisms. Current limitations in experimental systems to study infection and the lack of diagnostic tools still prevent a better understanding of Vibrio emergence. A major challenge is to foster cooperation between... |
| Tipo: Text |
Palavras-chave: Global warming; Human health; Aquaculture; Interactions; Animal model; Bacterial disease; Genome plasticity; European network. |
| Ano: 2015 |
URL: http://archimer.ifremer.fr/doc/00278/38952/37494.pdf |
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| Bai,Xiaofan; Liu,Guomin; Xu,Chuanjie; Zhuang,Yingying; Zhang,Jinlong; Jia,Yuyan; Liu,Yi. |
| Deer and sheep are used as spinal animal models in clinical and basic research. In this paper, the anatomical morphology, curvature, and morphology index parameters were investigated to assess the feasibility of using deer and sheep as animal models of the human spine. Fresh adult male sheep, deer, and human spine specimens (n = 10 each) were screened and subjected to morphological analyses. The statistical software package SPSS (version 17.0) was used to analyze the statistical similarity and variability among the 3 species. Deer displayed good similarity to human in terms of the vertebral transverse diameter, radius vector, spinal canal transverse diameter, radius vector, and vertebral upper and lower endplate curvature radii. Sheep displayed good... |
| Tipo: Journal article |
Palavras-chave: Lumbar spine; Animal model; Human; Deer; Sheep; Morphometry. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200025 |
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| Sarmento,José Lindenberg Rocha; Torres,Robledo de Almeida; Sousa,Wandrick Hauss de; Albuquerque,Lucia Galvão de; Lôbo,Raimundo Nonato Braga; Sousa,José Ernandes Rufino de. |
| Polynomial functions of age of different orders were evaluated in the modeling of the average growth trajectory in Santa Ines sheep in random regression models. Initially, the analyses were performed not considering the animal effect. Subsequently, the random regression analyses were performed including the random effects of the animal and its mother (genetic and permanent environment). The linear fit was lower, and the other orders were similar until near 100 days of age. The cubic function provided the closest fit of the observed averages, mainly at the end of the curve. Orders superior to this one tended to present incoherent behavior with the observed weights. The estimated direct heritabilities, considering the linear fit, were higher to those... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Breeding values; Fixed regression; Hairless sheep; Heritability; Polynomial functions. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982011000200012 |
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| Ribeiro,Jeferson Corrêa; Silva,Luciano Pinheiro da; Sousa,Mariele Freitas; Leite,Carla Daniela Suguimoto; Bonafé,Cristina Moreira; Caetano,Giovani da Costa; Crispim,Aline Camporez; Torres,Robledo de Almeida. |
| The objective of this study was to obtain estimates of genetic and phenotypic parameters for egg mass of meat quails and also to propose an optimal age for selection of birds through the egg mass. The data used in this study came from 3,503 female meat quails (UFV1: 1.811 quails; UFV2: 1.692 quails) of the Poultry Breeding Program from Universidade Federal de Viçosa. The traits examined were egg mass in partial periods until 77, 112, 147 and 182 days, and egg mass in the total period of 407 days by the use of single and bi-trait animal models. For the genetic group UFV1, the heritability values for the periods were high: 0.58, 0.59, 0.57, 0.59 and 0.24 (until 77, 112, 147,182 and 407 days, respectively). The values of genetic correlations were medium,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Coturnix coturnix; Egg weight; Genetic correlation; Heritability; Relative efficiency. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982012000500012 |
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| Silva,Adriana M. da; Flores,Eduardo F.; Weiblen,Rudi; Canto,Marister C.; Irigoyen,Luiz F.; Roehe,Paulo M.; Sousa,Renato S. de. |
| This article describes the main aspects of bovine herpesvirus type-5 (BHV-5) neurologic infection and disease in rabbits, a candidate animal model for studying BHV-5 neuropathogenesis. Intranasal inoculation of weanling rabbits with a Brazilian BHV-5 isolate produced neurological disease and death in 78.8% (26/33) of the animals. Neurological signs started as early as 5 days post-inoculation and lasted from 10-12 hours up to several days. Most animals evolved to a moribund state or death within 24 (69.2%) to 48 hours (88.5%). Neurological disease was characterized by excitability or depression, tremors, bruxism, walking or running in circles, backward arching of the head and body, incoordination, backward and sideways falling, paddling, profound depression... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bovine herpesvirus type-5; BHV-5; Meningoencephalitis; Rabbits; Animal model. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000100005 |
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| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; GRAFOVA,Iryna; NAIFF,Maricleide de Farias; AVELLA,Maurizio; GENTILE,Gennaro; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Topical formulations; Experimental treatment; Pentamidine isethionate; Animal model; Leishmania. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000100039 |
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| Dalzochio, Thaís; Nienov, Otto Henrique; Wannmacher, Clovis; Berlese, Daiane Bolzan; Feksa, Luciane Rosa. |
| Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Autoimmune disease; Enzymatic activity.. |
| Ano: 2019 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765 |
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| PACHECO,FELIPE D.; SILVA,MAURICIO L. DA; BATISTA,GRAZIELA; SANTOS,WITÓRIA; CASTRO,ADALBERTO A. DE; CANEVER,LARA; ZUGNO,ALEXANDRA I.. |
| ABSTRACT Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative symptoms, but it is not known whether antipsychotic use and/or withdrawal are implicated. Then, we tested clozapine withdrawal in association with two widely used schizophrenia models: Neonatal immune challenge by Polycitidilic-polyinosinic acid (polyI:C) and ketamine. PolyI:C (or saline) was injected subcutaneously in neonatal period, dose of 5 mg/kg from 2 to 6 Post Natal Days, and ketamine or saline at the dose 25mg/kg intraperitoneally (i.p.), daily for 7 days from 53 to 60 post natal day. Clozapine 10mg/kg (or saline) was administered i.p. from 46 to 60 post natal day. Olfactory discrimination... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Olfactory deficit; Clozapine; Schizophrenia; Animal model. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401659 |
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| Pinheiro,Simone H.; Zangrossi-Jr.,Hélio; Del-Ben,Cristina M.; Graeff,Frederico G.. |
| This article reviews reported results about the effects of drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, intracerebral drug administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of drugs on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Elevated maze; Anxiety; Panic; Serotonin. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100010 |
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| HOU,LIJUAN; LI,KE; HU,YANRU; BIAN,YIJUN; JI,WEI; SHI,KAIXUAN; LI,YITING; CHEN,MENGJIAO; LI,JIAXIN; LIU,XIAOLI; QIAO,DECAI. |
| Abstract: The mechanism behind exercise-induced fatigue is a significant topic in the field of sports physiology. Therefore, establishing and evaluating an acute exercise-induced fatigue animal model that explores the limits of the motor system may provide greater insight into these mechanisms. Heart rate is an important quantitative parameter that accurately reflects the immediate change in physical function due to exercise load. And there is likely to be an important correlation between heart rate and behavioral performance. In this study, changes in heart rate and behavioral indexes during exercise-induced fatigue were quantitatively analyzed in rats using heart rate telemetry and video methods respectively. The behavioral indexes were used as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise-induced fatigue; Animal model; Treadmill running; Heart rate. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700624 |
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| Muñoz,L.C.; Cardona.-Ramirez,S.; Silva,R.F.. |
| ABSTRACT Hydroxyapatite (HA) is widely used as a biomaterial for bone repair and metallic prostheses coating. The main limitations of the current commercial synthetic hydroxyapatite compounds include high cost and decreased availability, especially for veterinary medicine purposes. Additionally, it is thought that HA biocompatibility and bioactivity could be enhanced by the addition of metal compounds. The objective of this work was to compare the subcutaneous tissue response of commercial and engineered hydroxyapatite obtained from the bovine femur diaphysis mixed with different concentrations of hexa-hydrated Zinc Nitrate in rabbits. Twenty-Five New Zealand female rabbits were used. Five treatments were done according to HA composition (commercial HA, no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Biocompatibility; Bone; Integration. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601873 |
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| Li,Xiaofan; Song,Qingxiao; Hu1,Wanyu; Wan,Bo; Huang,Qinghua; Li,Qing. |
| ABSTRACT To establish a transfusion-associated graft-versus-host disease (TA-GVHD) mouse model with busulfan and fludarabine for effective treatment evaluation. BALB/c (H-2d) mice were injected with busulfan (15 mg/kg) and fludarabine (30 mg/kg) twice a day for 4 days. The mice were transfused with 106 T cell-depleted bone marrow (TCD-BM )and cells in different groups 3 days after chemotherapy: syngeneic BALB/c, MHC minor mismatch DBA/2 (H-2d), or MHC major mismatch C57BL/6(H2-b). Recipient BALB/c mice were injected with either blood only or blood+splenocyte. TA-GVHD was monitored in terms of body weight loss, clinical scores, and survival. Dexamethasone (50 mg/kg), cyclophosphamide (50 mg/kg), cyclosporine A (30 mg/kg), and anti-CD3 (1 mg/kg) were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Transfusion-associated graft-versus-host disease; Fludarabine; Busulfan; Animal model; Major histocompatibility complex. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100305 |
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| Rosa,Damiana Diniz; Reis,Sandra Aparecida dos; Siqueira,Nathane Pais; Gonçalves,Reggiani Vilela; Machado,Alessandra Barbosa Ferreira; Tafuri,Natália Filardis; Leite,João Paulo Viana; Matta,Sérgio Luís Pinto da; Peluzio,Maria do Carmo Gouveia. |
| ABSTRACTThe aim of this study was to investigate the effect of the bark extractBathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rats were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (treated with 200 mg/kg bark extract ofB. cuspidata), and B400 (treated with 400 mg/kg bark extract ofB. cuspidata). Administration of treatments was carried out by the gavage. The animals received four subcutaneous injections of 1,2-dimethylhydrazine (DMH, 40 mg/kg) in the initial two weeks of the experiment to induce preneoplastic colorectal lesions. After 15 weeks, the animals were euthanized and the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bathysa cuspidata; Animal model; Oxidative stress; Aberrant crypt foci. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000500732 |
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| Matos,Sheyla Leite; Paula,Heberth de; Pedrosa,Maria Lúcia; Santos,Rinaldo Cardoso dos; Oliveira,Eduardo Luiz de; Chianca Júnior,Deoclécio Alves; Silva,Marcelo Eustáquio. |
| The present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypercholesterolemia; Animal model; Caloric value; Cholesterol. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006 |
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| Registros recuperados: 34 | |
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