|
|
| LIMA,LUCIANA A.R.S.; ALVES,TÂNIA M.A.; ZANI,CARLOS L.; SALES JÚNIOR,POLICARPO A.; ROMANHA,ALVARO J.; JOHANN,SUSANA; CISALPINO,PATRÍCIA S.; PIMENTA,LÚCIA P.S.; BOAVENTURA,MARIA AMÉLIA D.. |
| Annona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma cruzi) and leishmanicidal (against Leishmania amazonensis) activities. Acetogenins presented cytotoxic activity confirming their potential use in anti-cancer therapy.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Annona cornifolia; Acetogenins; Cytotoxic; Antifungal; Trypanocidal; Leishmanicidal. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200829 |
| |
