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| Barreto-Bergter,Eliana; Pinto,Marcia R.; Rodrigues,Marcio L.. |
| Ceramide monohexosides (CMHs, cerebrosides) are glycosphingolipids composed of a hydrophobic ceramide linked to one sugar unit. In fungal cells, CMHs are very conserved molecules consisting of a ceramide moiety containing 9-methyl-4,8-sphingadienine in amidic linkage to 2-hydroxyoctadecanoic or 2-hydroxyhexadecanoic acids, and a carbohydrate portion consisting of one residue of glucose or galactose. 9-Methyl 4,8-sphingadienine-containing ceramides are usually glycosylated to form fungal cerebrosides, but the recent description of a ceramide dihexoside (CDH) presenting phytosphingosine in Magnaporthe grisea suggests the existence of alternative pathways of ceramide glycosylation in fungal cells. Along with their unique structural characteristics, fungal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glucosylceramide; Cerebrosides; Glycosphingolipids; Fungal pathogens; Antifungal therapy. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100007 |
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| Pereira,G.H.; Pádua,S.S.; Park,M.V.F.; Muller,R.P.; Passos,R.M.A.; Menezes,Y.. |
| Meningitis is a common evolution in progressive disseminated histoplasmosis in children, and is asymptomatic in many cases. In leukemia, the impaired of the T cells function can predispose to the disseminated form. The attributed mortality rate in this case is 20%-40% and the relapse rate is as high as 50%; therefore, prolonged treatment may be emphasized. We have described a child with acute myeloid leukemia (AML), that developed skin lesions and asymptomatic chronic meningitis, with a good evolution after prolonged treatment with amphotericin B deoxycholate followed by fluconazole. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histoplamosis; Chronic meningitis; Antifungal therapy. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600026 |
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| Corzo-León,Dora Edith; Perales-Martínez,Diana; Martin-Onraet,Alexandra; Rivera-Martínez,Norma; Camacho-Ortiz,Adrian; Villanueva-Lozano,Hiram. |
| ABSTRACT Background: Invasive fungal infections (IFIs) affect >1.5 million people per year. Nevertheless, IFIs are usually neglected and underdiagnosed. IFIs should be considered as a public-health problem and major actions should be taken to tackle them and their associated costs. Aim To report the incidence of IFIs in four Mexican hospitals, to describe the economic cost associated with IFIs therapy and the impact of adverse events such as acute kidney injury (AKI), liver damage (LD), and ICU stay. Methods: This was a retrospective, transversal study carried-out in four Mexican hospitals. All IFIs occurring during 2016 were included. Incidence rates and estimation of antifungal therapy's expenditure for one year were calculated. Adjustments for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fungal infections; Antifungal therapy; Cost; Acute kidney injury; Incidence rate; Mexico. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500360 |
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