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| Oliveira,Cláudia S.; Caldeira,Cleópatra A. S.; Diniz-Sousa,Rafaela; Romero,Dolores L.; Marcussi,Silvana; Moura,Laura A.; Fuly,André L.; Carvalho,Cicília de; Cavalcante,Walter L. G.; Gallacci,Márcia; Pai,Maeli Dal; Zuliani,Juliana P.; Calderon,Leonardo A.; Soares,Andreimar M.. |
| Abstract Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from five cnidarians: Millepora alcicornis, Stichodactyla helianthus, Plexaura homomalla, Bartholomea annulata and Condylactis gigantea (total and body wall). Methods: The cnidarian extracts were evaluated by electrophoresis and for their phospholipase, proteolytic, hemorrhagic, coagulant, fibrinogenolytic, neuromuscular blocking, muscle-damaging, edema-inducing and cytotoxic activities. Results: All... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caribbean sea cnidarians; Bioprospection; Antiophidic; Antitumor; Natural products. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100313 |
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