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| Venneri Mathias,Cícero; Simões,Manuel de Jesus; Mahmed Amed,Abes; Martins Oliveira-Filho,Ricardo; Venneri Mathias,Camila Fernandes; dos Santos Simões,Ricardo; Kulay Júnior,Luiz. |
| There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this study was to evaluate the effects of foscarnet on the entire period of rat pregnancy. Female pregnant rats were randomly assigned to four treatment groups (n = 10): one control (C) treated with the drug vehicle (bidestilled water) and three experimental groups (E1, E2 and E3) treated with 180, 360 or 720 mg/Kg of foscarnet, respectively. Rats were treated by gavage once daily. The treatment period extended from the first until the 20th day of pregnancy. Body... |
| Tipo: Journal article |
Palavras-chave: Antiretroviral drugs; Foscarnet; Pregnancy; Rat. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200008 |
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| Cristelli,Marina Pontello; Trullàs,Joan Carles; Cofán,Federico; Rico,Naira; Manzardo,Christian; Ambrosioni,Juan; Bedini,Josep Lluis; Moreno,Asunción; Diekmann,Fritz; Miro,Jose Maria. |
| ABSTRACT Background In people living with HIV, much is known about chronic kidney disease, defined as a glomerular filtration rate under 60 mL/min. However, there is scarce data about prevalence and risk factors for milder impairment (60-89 mL/min). Objective The present study aims to assess the influence of sex, antiretroviral therapy, and classical risk factors on the occurrence of mild decreased renal function in a large Spanish cohort of HIV-infected patients. Methods Cross-sectional, single center study, including all adult HIV-1-infected patients under antiretroviral treatment with at least two serum creatinine measures during 2014, describing the occurrence of and the risk factors for mildly decreased renal function (eGFR by CKD-EPI creatinine... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV-infection; Antiretroviral drugs; Chronic kidney disease; Glomerular filtration rate estimates. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300193 |
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| Andrade,Carolina Horta; Freitas,Lenis Medeiros de; Oliveira,Valéria de. |
| From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable. Currently, there are twenty-five anti-HIV compounds which have been formally approved for clinical use in the treatment of AIDS. These compounds fall into six categories: nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), cell entry inhibitors or fusion inhibitors (FIs), co-receptor inhibitors (CRIs), and integrase inhibitors (INIs). Metabolism by the host organism is one of the most important determinants of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS/treatment; Drugs/anti-HIV; Drugs/metabolism; Antiretroviral drugs; Biotransformation. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200003 |
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