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Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins Biota Neotropica
Agripino,Débora Gomes; Lima,Marcos Enoque Leite; Silva,Marcelo Rogério da; Meda,Cristiane Infante; Bolzani,Vanderlan da Silva; Cordeiro,Inês; Young,Maria Claudia Marx; Moreno,Paulo Roberto H..
I. Atlantic Rain Forest . Ecological Station Juréia-Itatins) Crude extracts from 88 plant species occurring in São Paulo State (Brazil), collected in an Atlantic Forest region, have been screened for antimicrobial and DNA-damaging activities. Of the 114 extracts assayed for antibacterial activity, only the extracts from leaves and stems of Aspidosperma ramiflorum (Apocynaceae) showed a slight activity against Escherichia coli. In the antifungal assay with Candida albicans, no active extract was observed, while in the bioautography assay with Cladosporium sphaerospermum and C. cladosporioides 12% were active. However, only the extract of Psychotria mapoureoides (Rubiaceae) stems showed a strong inhibition of both fungi. The DNA-damaging assay with mutant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Atlantic Rain forest; Antibacterial activity; Antifungal activity; Antitumoral activity; Plants screening.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032004000200009
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In Vitro study of Vellozia pusilla pohl (Velloziaceae), a Brazilian plant species: antitumoral activity and labeling of blood elements BABT
Dantas,Ana Letícia Almeida; Valente,Lígia Maria Marino; Morais,Lilia Aparecida Salgado de; Feliciano,Glaucio; Bernardo-Filho,Mário.
Vellozia pusilla Pohl is a species of the botanic family Velloziaceae that occurs in the subtropical regions of South America and, although it lives under conditions of high solar irradiation and low water availability, shows great longevity. The methanol extract of roots, stem and leaf sheaths of this species showed an antitumoral activity through the inhibition of the enzyme Topoisomerase I when analyzed by an in vitro bioassay employing DNA repair or recombination deficient mutants of the yeast Saccharomyces cerevisiae. In the evaluation of the effect of Vellozia pusilla methanol extract on the labeling of RBC, blood of mice was treated with 99mTc tracer solutions. The percentage of radioactivity (%ATI) bound to plasma (P) and blood cells (BC) was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Antitumoral activity; Technetium-99m; Blood elements; Velloziaceae.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700008
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