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| Teixeira-Araújo,Ricardo; Castanheira,Patrícia; Brazil-Más,Leonora; Pontes,Francisco; Araújo,Moema Leitão de; Alves,Maria Lucia Machado; Zingali,Russolina Benedeta; Correa-Netto,Carlos. |
| Abstract Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA. However, each institution uses its own mixture of rattlesnake venom antigens. Previous works have shown that crotamine, a toxin found in Crolatus durissus venom, shows marked individual and populational variation. In addition, serum produced from... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Antivenom production; Antivenomics; Crotalus durissus; Crotamine; Crotoxin; Geographic venom variation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100602 |
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| Morais,V.; Baraibar,M.; Carreira,S.. |
| In Uruguay, there was no information about the variations degree in Bothrops pubescens venoms until the present work, in which we investigated intraspecific venom variation using polyacrylamide gel electrophoresis (SDS-PAGE). We found some differences in the venom protein profile; however, they were not related to the parameters studied (geographic distribution, weight, sex, and captivity time). Moreover, we distinguished two different groups in relation to band densities at 49 and 57 kDa. Specimens with predominant density in the 49kDa band tend to be predominantly females. Weight distribution in this group extended for all the range (150-1500 g) with an average weight of 720 g. The other group (57kDa predominant band) showed restricted weight range... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Venom; Bothrops pubescens; Uruguay; Antivenom production; Electrophoretic pattern. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400007 |
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