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In vitro investigations of Cynara scolymus L. extract on cell physiology of HepG2 liver cells BJPS
Löhr,Gesine; Deters,Alexandra; Hensel,Andreas.
The objective of this study was the investigation of a potential influence of artichoke leaf extract (ALE) on the cell physiology and gene expression of phase I/II enzymes of human liver cells HepG2 and investigation on potential cell protective effects against ethanol-induced cell toxicity against HepG2 cells. Cell biological assays under in vitro conditions using HepG2 liver cells and investigation of mitochondrial activity (MTT test), proliferation assay (BrdU incorporation ELISA), LDH as toxicity marker, gene expression analysis by RT-PCR and enzyme activity of glutationtransferase. Artichocke extract, containing 27% caffeoylquinic acids and 7% flavonoids induced mitochondrial activity, proliferation and total protein content under in vitro conditions...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cynara scolymus L. Asteraceae; Artichoke; Liver cells; Cell proliferation; Gene expression.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200003
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Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster Genet. Mol. Biol.
Jacociunas,Laura Vicedo; Dihl,Rafael Rodrigues; Lehmann,Mauricio; Ferraz,Alexandre de Barros Falcão; Richter,Marc François; Silva,Juliana da; Andrade,Heloísa Helena Rodrigues de.
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE. In contrast, co-treatment with BHE significantly enhanced the EMS-induced genotoxicity involving mutagenic and/or recombinant events. Co-treatment with LE did not alter the genotoxicity of EMS whereas post-treatment with the highest dose of LE significantly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Artichoke; Drosophila melanogaster; Recombinogenicity; SMART.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100015
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ผลิตผล: ผลผลิตสด "ดี อร่อย" ที่ดอยอ่างขาง Thai Agricultural
Anut Charoenpong.
Tipo: Collection Palavras-chave: Peach; Strawberry; Kiwifruit; Japanese apricot; Persimmon; Plum; Asian pear; Avocado; Pointed cabbage; Cos lettuce; Artichoke; Rhubarb; พี้ช; สตรอเบอรี่; กีวีฟรุ้ท; บ๊วย; พลับ; พลัม; สาลี่; อะโวกาโด; กะหล่ำปลีรูปหัวใจ; คอสสลัด; อาร์ติโช๊ค; รูบาร์บ; สถานีเกษตรหลวงอ่างขาง.
Ano: 2009 URL: http://anchan.lib.ku.ac.th/agnet/handle/001/5064
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