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| Martins,Marielza R Ismael; Azoubel,Reinaldo. |
| The objective of this study was the evaluation of aspartame effects on morphometric alterations of the glomerulus, proximal and distal convoluted tubules and collecting ducts of the rat fetal kidney during organogénesis. Fifteen pregnant rats averaging 24 g body weight, were divided into 3 groups (n=5 each) of controls, rats treated with aspartame exposed to room temperature and rats treated with aspartame heated to 40°C. Animals were given 14mg / kg aspartame by the intragastric route on the 9th, 10th, and 11th days of pregnancy. Karyometric and stereological techniques estimated morphological changes. A significant decrease of fetal body weight was observed in the group given aspartame kept at room temperature, compared to controls. Karyometry permitted... |
| Tipo: Journal article |
Palavras-chave: Aspartame; Kidney; Morphometry. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400004 |
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| Leme,Fabíola Azevedo Genovez de Lima; Azoubel,Reinaldo. |
| The present study evaluated the effects of the sweetener aspartame on the fetal pancreas, through a morphometric study, with the objective of studying the exocrine pancreas at the end of gestational development. For this we utilized two treated groups, one with a solution of aspartame at ambient temperature and the other with an aspartame solution heated to 40C, and two groups treated with water ad libitum, at ambient temperature and heated to 40C, respectively. On the final day of gestation the fetuses were removed and the pancreas was collected for microscopic analysis. The morphometric study demonstrated alteration in eight out of the eleven parameters studied in the group treated with the heated solution and one parameter altered in the group treated... |
| Tipo: Journal article |
Palavras-chave: Aspartame; Pancreas; Fetus. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500027 |
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| Silva,A.E.; Souza,M.A.; Gomes,M.S.C.; Souza,E.C.M.; Frazão,M.F.; D'assunção,C.G.; Maia,C.S.; Tenório,F.C.A.M.; Soares,J.K.B.. |
| RESUMO Nos últimos anos, tem-se observado um aumento no consumo de alimentos diet e light por adolescentes ou por aqueles que estão à procura de uma alimentação com baixo teor calórico, surgindo, assim, diversos edulcorantes, como o aspartame. Porém, seu consumo ainda gera polêmica, devido a muitos dados contraditórios e inconclusivos. Diante disso, objetivou-se avaliar os efeitos da suplementação de aspartame sobre ingestão alimentar, parâmetros físicos, bioquímicos e histopatológicos em 18 ratos machos da linhagem Wistar, com cinco semanas de vida (ratos jovens), tratados durante 21 dias. Os animais foram distribuídos aleatoriamente em dois grupos: grupo controle (GC) - tratados com água destilada por gavagem, e o grupo aspartame (GA) - tratados... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aspartame; Peso corpóreo; Ingestão alimentar. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000601516 |
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