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	Provedor de dados BJMBR (3) BJID (1) Autor Angeli,C.B. (1) Bastos,A.Q.A. (1) Benseñor,I. (1) Canani,L.H.S. (1) Castro,I.M. (1) Cândido,A.P.C. (1) Errera,F.I.V. (1) Freitas,R.N. (1) Kimura,L. (1) Krieger,J.E. (1) Lotufo,P.A. (1) Machado-Coelho,G.L.L. (1) Mingroni-Netto,R.C. (1) Mota,G.A. (1) Passos-Bueno,M.R. (1) Pereira,A.C. (1) Queiroz,E.M. (1) Silva,M.E.R. (1) Yan,Fu-tang (1) Yeh,E. (1) Mais... Palavra-chave Association study (4) ACE (1) Adiponectin receptors (1) Angiotensin-converting enzyme (1) Angiotensinogen (1) Association of ADIPOR1 with DM2 (1) Brazilian population (1) Genetic polymorphisms (1) Genetics (1) HBV (1) HDL cholesterol (1) Hypertension (1) Obesity (1) PRKAA1 gene (1) Polymorphism for ancestry-admixture mapping (1) SNP (1) Type 2 diabetes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2016 (1) 2015 (1) 2008 (1) 2001 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population BJID Yuan,Jun; Zhang,Yan; Yan,Fu-tang; Zheng,Xiao. ABSTRACT Objective: Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study. Methods: We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested. Results: Rs1002424 polymorphism showed significant difference in the allele frequencies, but... Tipo: Info:eu-repo/semantics/article Palavras-chave: HBV; PRKAA1 gene; SNP; Association study. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600564 Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies BJMBR Pereira,A.C.; Mota,G.A.; Benseñor,I.; Lotufo,P.A.; Krieger,J.E.. Previous genetic association studies have overlooked the potential for biased results when analyzing different population structures in ethnically diverse populations. The purpose of the present study was to quantify this bias in two-locus association studies conducted on an admixtured urban population. We studied the genetic structure distribution of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen methionine/threonine (M/T) polymorphisms in 382 subjects from three subgroups in a highly admixtured urban population. Group I included 150 white subjects; group II, 142 mulatto subjects, and group III, 90 black subjects. We conducted sample size simulation studies using these data in different genetic models of gene action and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Association study; Genetics; Angiotensin-converting enzyme; ACE; Angiotensinogen. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100008 IGF2, LEPR, POMC, PPARG, and PPARGC1 gene variants are associated with obesity-related risk phenotypes in Brazilian children and adolescents BJMBR Queiroz,E.M.; Cândido,A.P.C.; Castro,I.M.; Bastos,A.Q.A.; Machado-Coelho,G.L.L.; Freitas,R.N.. Association studies of genetic variants and obesity and/or obesity-related risk factors have yielded contradictory results. The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes. This case-control study assessed overweight (n=192) and normal-weight (n=211) children and adolescents. The SNPs were analyzed using minisequencing assays, and variables and genotype distributions between the groups were compared using one-way analysis of variance and Pearson's chi-square or Fisher's exact tests. Logistic regression analysis adjusted for age and gender was used to calculate the odds ratios (ORs)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Association study; Obesity; Genetic polymorphisms; Brazilian population. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700595 Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry BJMBR Yeh,E.; Kimura,L.; Errera,F.I.V.; Angeli,C.B.; Mingroni-Netto,R.C.; Silva,M.E.R.; Canani,L.H.S.; Passos-Bueno,M.R.. Association studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G>A and SNP c.10225C>G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of European (EA; N = 443) or African (AfA; N = 124) ancestry from rural (quilombo remnants; N = 439) and urban (N = 567) areas. We detected a significant effect of ethnicity on the distribution of the allelic frequencies of both SNPs in these populations (EA: -8503A = 0.27; AfA: -8503A = 0.16; P = 0.001 and EA: 10225G = 0.35; AfA: 10225G = 0.51; P < 0.001). Neither of the polymorphisms were associated with DM2 in the case-control study in EA (SNP c.-8503G>A: DM2... Tipo: Info:eu-repo/semantics/other Palavras-chave: Association study; Adiponectin receptors; Type 2 diabetes; Polymorphism for ancestry-admixture mapping; HDL cholesterol; Association of ADIPOR1 with DM2. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600005 Registros recuperados: 4 Primeira ... 1 ... Última

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