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Experimental model of heterotopic ossification in Wistar rats BJMBR
Zotz,T.G.G.; Paula,J.B. de; Moser,A.D.L..
Heterotopic ossification (HO) is a metaplastic biological process in which there is newly formed bone in soft tissues adjacent to large joints, resulting in joint mobility deficit. In order to determine which treatment techniques are more appropriate for such condition, experimental models of induced heterotopic bone formation have been proposed using heterologous demineralized bone matrix implants and bone morphogenetic protein and other tissues. The objective of the present experimental study was to identify a reliable protocol to induce HO in Wistar rats, based on autologous bone marrow (BM) implantation, comparing 3 different BM volumes and based on literature evidence of this HO induction model in larger laboratory animals. Twelve male Wistar albino...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heterotopic ossification; Autologous bone marrow; Serum alkaline phosphatase.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600004
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