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Functionality of innovative and generic celluloses in metronidazole formulations BJPS
Díaz Ramírez,Carmen Cristina; Villafuerte Robles,Leopoldo.
The wide variety of excipients available calls for evaluation of their functionality, in this case of the pharmaceutical performance of microcrystalline celluloses and sodium cross-linked carboxymethylcelluloses from different sources. This evaluation includes parameters such as powder flow, compactibility, ejection pressure and dissolution from fast-release tablets as well as from floating granules and controlled-release tablets. In a previous study, the excipient Carmacel® presented better disintegration properties compared to Croscarmellose®. However, the evaluation showed better compactibility performance for Croscarmellose®. These characteristics were observed using pure excipients. Nevertheless, these advantages have not been confirmed in tests...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Excipients/functionality; Microcrystalline celluloses; Sodium cross-linked carboxymethylcelluloses; Croscarmellose; Carmacel; Avicel; Alfacel; Tablets/disintegrants; Pharmaceutical dosage/forms.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100006
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Use of remazol blue dyed avicel for the determination of cellulolytic activity in basidiomycetes Rev. Microbiol.
Correia,Marcos José; Pereira Junior,José Antônio de Sousa; Santos,Jefferson Cunha dos; Cavalcanti,Maria Auxiliadora de Queiroz.
A modified method for direct determination of cellulolytic activity using Avicel colored with Remazol Brilliant Blue R (RBBR) in Agar test tubes is discussed. Refinements were introduced in a simple method for quantitation of cellulase activity, based on the release of dye from Avicel-RBBR medium by the enzymatic hydrolysis. Modifications in Avicel-dye preparation were enhanced and a spectrophotometer for direct OD measurement in agar test tubes used. The use of a spectrophotometer improved the precision of the collected data, since absorbance measurements could be done at the maximum wavelenght for RBBR (595 nm).
Tipo: Info:eu-repo/semantics/article Palavras-chave: Avicel; Cellulase; Remazol Blue; Lentinus edodes; Pleurotus ostreatus.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400010
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