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Comparison of three methods for the determination of baroreflex sensitivity in conscious rats BJMBR
Farah,V.M.A.; Moreira,E.D.; Pires,M.D.; Irigoyen,M.C.C.; Krieger,E.M..
Baroreflex sensitivity was studied in the same group of conscious rats using vasoactive drugs (phenylephrine and sodium nitroprusside) administered by three different approaches: 1) bolus injection, 2) steady-state (blood pressure (BP) changes produced in steps), 3) ramp infusion (30 s, brief infusion). The heart rate (HR) responses were evaluated by the mean index (mean ratio of all HR changes and mean arterial pressure (MAP) changes), by linear regression and by the logistic method (maximum gain of the sigmoid curve by a logistic function). The experiments were performed on three consecutive days. Basal MAP and resting HR were similar on all days of the study. Bradycardic responses evaluated by the mean index (-1.5 ± 0.2, -2.1 ± 0.2 and -1.6 ± 0.2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Baroreflex; Baroreceptor; Bradycardia; Tachycardia.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300018
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