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	Provedor de dados BABT (2) BJMBR (1) Autor Bernardo-Filho,M. (1) Bernardo-Filho,Mario (1) Bernardo-Filho,Mário (1) Carvalho,J.J. (1) Dantas,Ana Letícia Almeida (1) De-Paula,E.F. (1) Feliciano,Glaucio (1) Fonseca,L.M. (1) Freitas,L.C. (1) Gomes,Maria Luisa (1) Gutfilen,B. (1) Morais,Lilia Aparecida Salgado de (1) Oliveira,Marcia B. Nunes de (1) Pereira,M.J.S. (1) Pôrto,L.C.M.S. (1) Ripoll-Hamer,E. (1) Valente,Lígia Maria Marino (1) Mais... Palavra-chave Blood elements (3) Drug interaction (2) Radiopharmaceuticals (2) Antitumoral activity (1) Bioavailability (1) Radioautography (1) Technetium-99m (1) Velloziaceae (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2005 (1) 2002 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals BABT Gomes,Maria Luisa; Oliveira,Marcia B. Nunes de; Bernardo-Filho,Mario. The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are the possibility of misdiagnosis and/or the repetition of the examination with an increase of radiation dose to the patient. The possible explanation to the appearance... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Blood elements; Radiopharmaceuticals; Bioavailability. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500020 In Vitro study of Vellozia pusilla pohl (Velloziaceae), a Brazilian plant species: antitumoral activity and labeling of blood elements BABT Dantas,Ana Letícia Almeida; Valente,Lígia Maria Marino; Morais,Lilia Aparecida Salgado de; Feliciano,Glaucio; Bernardo-Filho,Mário. Vellozia pusilla Pohl is a species of the botanic family Velloziaceae that occurs in the subtropical regions of South America and, although it lives under conditions of high solar irradiation and low water availability, shows great longevity. The methanol extract of roots, stem and leaf sheaths of this species showed an antitumoral activity through the inhibition of the enzyme Topoisomerase I when analyzed by an in vitro bioassay employing DNA repair or recombination deficient mutants of the yeast Saccharomyces cerevisiae. In the evaluation of the effect of Vellozia pusilla methanol extract on the labeling of RBC, blood of mice was treated with 99mTc tracer solutions. The percentage of radioactivity (%ATI) bound to plasma (P) and blood cells (BC) was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Antitumoral activity; Technetium-99m; Blood elements; Velloziaceae. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700008 In vitro radioautographic studies of the biodistribution of radiopharmaceuticals on blood elements BJMBR Ripoll-Hamer,E.; De-Paula,E.F.; Freitas,L.C.; Pereira,M.J.S.; Fonseca,L.M.; Gutfilen,B.; Carvalho,J.J.; Pôrto,L.C.M.S.; Bernardo-Filho,M.. In the present study we evaluated the binding of the radiopharmaceuticals sodium pertechnetate (Na 99mTcO4), methylenediphosphonic acid (99mTc-MDP) and glucoheptonate acid (99mTc-GHA) to blood elements using centrifugation and radioautographic techniques. Heparinized blood was incubated with the labelled compounds for 0, 1, 2, 3, 4, 6 and 24 h. Plasma (P) and blood cells (BC) were isolated and precipitated with 5% trichloroacetic acid (TCA), and soluble (SF) and insoluble fractions (IF) were separated. Blood samples were prepared (0 and 24 h) and coated with LM-1 radioautographic emulsions and percent radioactivity (%rad) in P and BC was determined. The binding of Na 99mTcO4 (%rad) to P was 61.2% (0 h) and 46.0% (24 h), and radioautography showed 63.7% (0... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radioautography; Radiopharmaceuticals; Blood elements. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200014 Registros recuperados: 3 Primeira ... 1 ... Última

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