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Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Maleki,Alireza; Kiani,Mossa; Asadi,Ebrahim; Farsi,Mirmerhdad.
Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four groups. Case group received 600 (treatment I) and 1200 (treatment II) mg/kg/day the hydroalcoholic extract of Mentha piperita during 6-15 of gestational days and one control group received normal saline during GD6-GD15 by gavages and other control group did not receive any matter during 6-15 of gestational days. Mice sacrificed at GD18 and embryos were collected. Macroscopic observation was done by stereomicroscope. 20 fetuses of each group were stained by Alizarin...
Tipo: Journal article Palavras-chave: Mentha piperita; Teratogen; Bone ossification; Developmental toxicity; Mice.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300033
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