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	Provedor de dados Electron. J. Biotechnol. (2) CIGR Journal (1) BABT (1) BJM (1) BJPS (1) Autor Bisht,Deepali (1) Chen,Fang (1) Darmwal,Nandan Singh (1) Ghosh, Payel (1) Li,Shanshan (1) Mandal,Snigdha Das (1) Mandal,Surjyanarayan (1) Mo,Jixian (1) Patel,Dhaval J (1) Patel,Jayvadan (1) Patel,Jayvadan K (1) Pradhan, Rama Chandra (1) Swaraj, Nikhil (1) Wang,Zhigang (1) Wei,Lei (1) Xu,Weihui (1) Xu,Ying (1) Yadav,Santosh Kumar (1) Yan,Fang (1) Yin,Li (1) Mais... Palavra-chave Box-Behnken design (6) Alkaline lipase (1) Aspergillus ficcum (1) Bacillus (1) Curcumin/neuroprotective effect (1) Dimethyl phthalate (1) Enzymatic extraction (1) Famotidine (1) Jamun (Indian black berry) (1) Male mice C57BL/6 (1) Medium optimization (1) Mucoadhesion (1) Nanosuspension (1) Neurodegradation (1) Optimization (1) Parkinson's disease/treatment (1) Peptic ulcer (1) Plackett-Burman design (1) Pseudomonas aeruginosa (1) Radical scavenging activity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Journal article (2) Ano 2021 (1) 2017 (1) 2015 (2) 2013 (2) País Brazil (3) Chile (2) China (1) Idioma Inglês (6)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 6 Primeira ... 1 ... Última Effect of Tannase (Aspergillus ficcum) on physicochemical properties of clarified Jamun juice CIGR Journal Ghosh, Payel; Swaraj, Nikhil; Pradhan, Rama Chandra. Indian black berry known as Jamun is a minor fruit which contains high amount of tannin. Extraction and clarification of juice is quite difficult due to its pulp nature. Tannase a membrane bound enzyme is added to clarify the Jamun juice which helps to obtain high yield. The target area of the work is to build up the procedure for streamlining of process factor to obtain Jamun juice utilizing Tannase (strain: Aspergillus ficcum). Physicochemical parameters (clarity, colour change, polyphenol, turbidity, protein, TSS and yield) are analyzed at a temperature range between (30 – 50oC), with (0.01 – 0.1 % w/v) concentration and time orbit of (40-120 min). Significant differences in the response characteristics were measured using coefficient of determination... Tipo: Info:eu-repo/semantics/article Palavras-chave: Jamun (Indian black berry); Enzymatic extraction; Tannase; Aspergillus ficcum; Box-Behnken design; Optimization. Ano: 2021 URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/6307 Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment BABT Patel,Dhaval J; Patel,Jayvadan K. The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Famotidine; Nanosuspension; Box-Behnken design; Mucoadhesion; Peptic ulcer. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200007 Computation of interactive effects and optimization of process parameters for alkaline lipase production by mutant strain of Pseudomonas aeruginosa using response surface methodology BJM Bisht,Deepali; Yadav,Santosh Kumar; Darmwal,Nandan Singh. Alkaline lipase production by mutant strain of Pseudomonas aeruginosa MTCC 10,055 was optimized in shake flask batch fermentation using response surface methodology. An empirical model was developed through Box-Behnken experimental design to describe the relationship among tested variables (pH, temperature, castor oil, starch and triton-X-100). The second-order quadratic model determined the optimum conditions as castor oil, 1.77 mL.L-1; starch, 15.0 g.L-1; triton-X-100, 0.93 mL.L-1; incubation temperature, 34.12 ºC and pH 8.1 resulting into maximum alkaline lipase production (3142.57 U.mL-1). The quadratic model was in satisfactory adjustment with the experimental data as evidenced by a high coefficient of determination (R²) value (0.9987). The RSM... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alkaline lipase; Box-Behnken design; Pseudomonas aeruginosa; Response surface methodology. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100035 Intranasal mucoadhesivemicroemulsion for neuroprotective effect of curcuminin mptp induced Parkinson model BJPS Mandal,Snigdha Das; Mandal,Surjyanarayan; Patel,Jayvadan. ABSTRACT This study was to investigate the neuroprotective effect of curcumin against inflammation-mediated dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD). Curcumin loaded sodium hyaluronate based mucoadhesive microemulsion (CMME) was developed by using Box Behnken design of Response surface method (RSM) and was characterized. Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed CMME intranasal administration for 14 days at 2.86 mg of curcumin/kg of body weight per once a day. Optimal CMME containing 3% Capmul MCM as oil phase, 37 % of Accenon CC and Transcutol HP at 2.5:1 ratio and 0.5% sodium... Tipo: Info:eu-repo/semantics/article Palavras-chave: Curcumin/neuroprotective effect; Response surface methodology (RSM); Box-Behnken design; Sodium hyaluronate; Neurodegradation; Parkinson's disease/treatment; Male mice C57BL/6. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200621 Extraction optimization of total triterpenoids from Jatropha curcas leaves using response surface methodology and evaluations of their antimicrobial and antioxidant capacities Electron. J. Biotechnol. Wei,Lei; Zhang,Wei; Yin,Li; Yan,Fang; Xu,Ying; Chen,Fang. Background Triterpenoids are multifunctional secondary metabolites in plants. But little information is available concerning the actual yield, optimal extraction method and pharmacologic activity with regard to triterpenoids from Jatropha curcas leaves (TJL). Hence, response surface methodology (RSM) was used to optimize the extraction parameters. The effects of three independent variables, namely liquid-to-solid ratio, ethanol concentration and extraction time on TJL yield were investigated. TJL obtained by silica column chromatography was tested against bacterial and fungal species relevant to oral disease and wounds through broth microdilution. Antioxidant activity was assessed using the 2,2-diphenyl-2-picrylhydrazyl and... Tipo: Journal article Palavras-chave: Box-Behnken design; Radical scavenging activity; Ultrasound-assistant extraction. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000200005 Enhanced production of dimethyl phthalate-degrading strain Bacillus sp. QD14 by optimizing fermentation medium Electron. J. Biotechnol. Mo,Jixian; Wang,Zhigang; Xu,Weihui; Li,Shanshan; Yu,Zhidan. Background Integrated statistical experimental designs were applied to optimize the medium constituents for the production of a dimethyl phthalate (DMP)-degrading strain Bacillus sp. QD14 in shake-flask cultures. A Plackett-Burman design (PBD) was applied to screen for significant factors, followed by the Steepest Ascent Method (SAM) to find the nearest region of maximum response. A Box-Behnken design (BBD) of the Response Surface Methodology (RSM) was conducted to optimize the final levels of the medium components. Results After the regression equation and response surface contour plots were analyzed, the concentrations of glucose, corn meal and NaCl were found to significantly influence the biomass of DMP-degrading bacteria. A combination of 22.88 g/L of... Tipo: Journal article Palavras-chave: Bacillus; Box-Behnken design; Dimethyl phthalate; Medium optimization; Plackett-Burman design. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300016 Registros recuperados: 6 Primeira ... 1 ... Última

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