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Novel Tc-99m radiotracers for brain imaging BABT
Boschi,Alessandra; Pasquali,Micol; Uccelli,Licia; Duatti,Adriano.
A novel class of Tc-99m complexes able to cross the blood brain barrier has been investigated and described here. These compounds are formed by reacting the bis-substituted nitrido precusors [99mTc(N)(PS)2] (PS = phosphino-thiol ligand) with triethylborane (BEt3) under strictly anhydrous conditions and using non-aqueous solvents. The molecular structure of these tracers was not fully established, but preliminary experimental evidence suggests that they result from the interaction of the Lewis base [99mTc(N)(PS)2] with the Lewis acid BEt3, which leads to the formation of the novel -B-N<FONT FACE=Symbol>º</FONT> Tc- adduct. After purification and recovery in a physiological solution, the new borane-nitrido Tc-99m derivatives were injected in rats...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brain imaging; Nitrido complexes; Technetium-99m.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600005
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Optical coherence tomography imaging of the basal ganglia: feasibility and brief review BJMBR
Lopez,W. O. Contreras; Ângelos,J. S.; Martinez,R. C. R.; Takimura,C. K.; Teixeira,M. J.; Lemos Neto,P. A.; Fonoff,E. T..
Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Optical coherence tomography (OCT); Basal ganglia; Rat brain; Brain imaging; Histology; Thalamus.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201156
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Using Biomedical Technologies to Inform Economic Modeling: Challenges and Opportunities for Improving Analysis of Environmental Policies AgEcon
Roe, Brian E.; Haab, Timothy C..
Advances in biomedical technology have irrevocably jarred open the black box of human decision making, offering social scientists the potential to validate, reject, refine and redefine the individual models of resource allocation that form the foundation of modern economics. In this paper we (1) provide a comprehensive overview of the biomedical methods that may be harnessed by economists and other social scientists to better understand the economic decision making process; (2) review research that utilizes these biomedical methods to illuminate fundamental aspects of the decision making process; and (3) summarize evidence from this literature concerning the basic tenants of neoclassical utility that are often invoked for positive welfare analysis of...
Tipo: Conference Paper or Presentation Palavras-chave: Neuroeconomics; Neuroscience; Brain imaging; Genetics; Welfare economics; Utility theory; Biology; Decision making; Preferences; Institutional and Behavioral Economics; Research Methods/ Statistical Methods; D01; D03; D6; D87.
Ano: 2009 URL: http://purl.umn.edu/49151
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