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	Provedor de dados BJMBR (1) Autor Deng,L.J. (1) Liu,X.J. (1) Tian,K.Y. (1) Wang,G. (1) Xu,J.D. (1) Palavra-chave Apoptosis (1) Burn injury (1) Endothelial cells (1) Hyperpermeability (1) Propofol (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2015 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Propofol inhibits burn injury-induced hyperpermeability through an apoptotic signal pathway in microvascular endothelial cells BJMBR Tian,K.Y.; Liu,X.J.; Xu,J.D.; Deng,L.J.; Wang,G.. Recent studies have revealed that an intrinsic apoptotic signaling cascade is involved in vascular hyperpermeability and endothelial barrier dysfunction. Propofol (2,6-diisopropylphenol) has also been reported to inhibit apoptotic signaling by regulating mitochondrial permeability transition pore (mPTP) opening and caspase-3 activation. Here, we investigated whether propofol could alleviate burn serum-induced endothelial hyperpermeability through the inhibition of the intrinsic apoptotic signaling cascade. Rat lung microvascular endothelial cells (RLMVECs) were pretreated with propofol at various concentrations, followed by stimulation with burn serum, obtained from burn-injury rats. Monolayer permeability was determined by transendothelial electrical... Tipo: Info:eu-repo/semantics/article Palavras-chave: Burn injury; Hyperpermeability; Propofol; Apoptosis; Endothelial cells. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000500401 Registros recuperados: 1 Primeira ... 1 ... Última

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