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	Provedor de dados BJMBR (1) Autor Abreu,J.G. (1) Aguiar,D.P. (1) Coelho-Aguiar,J.M. (1) Palavra-chave Adhesion (1) CCN family (1) CCN2/CTGF (1) Condensation (1) Extracellular matrix (1) Teratocarcinoma (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell BJMBR Aguiar,D.P.; Coelho-Aguiar,J.M.; Abreu,J.G.. Connective tissue growth factor (CCN2/CTGF) is a matricellular-secreted protein involved in extracellular matrix remodeling. The P19 cell line is an embryonic carcinoma line widely used as a cellular model for differentiation and migration studies. In the present study, we employed an exogenous source of CCN2 and small interference RNA to address the role of CCN2 in the P19 cell aggregation phenomenon. Our data showed that increasing CCN2 protein concentrations from 0.1 to 20 nM decreased the number of cell clusters and dramatically increased cluster size without changing proliferation or cell survival, suggesting that CCN2 induced aggregation. In addition, CCN2 specific silencing inhibited typical P19 cell aggregation, which could be partially rescued by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Teratocarcinoma; Adhesion; Condensation; CCN family; CCN2/CTGF; Extracellular matrix. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000300004 Registros recuperados: 1 Primeira ... 1 ... Última

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