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	Provedor de dados BJMBR (4) Autor Alves-Do-Prado,W. (1) Branco,L.G.S. (1) Carvalho,A.F. (1) Carvalho-Costa,P.G. (1) Fonteles,M.C. (1) Forte,L.R. (1) Kadekaro,M. (1) Leite-Panissi,C.R.A. (1) Queiroz,R.N. (1) Ramos,E.R.P. (1) Santos-Neto,M.S. (1) Mais... Palavra-chave CGMP (4) ANP (1) Acute stress (1) Antinociception (1) Carbon monoxide (1) Guanylin (1) Heme oxygenase (1) K+ channel (1) Kidney (1) L-NAME (1) L-arginine (1) Lateral cerebral ventricle (1) Microdialysis (1) Natriuresis (1) Nitric oxide (1) ODQ (1) Oxytocin (1) Skeletal muscle (1) Tetanic fade (1) Uroguanylin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2014 (1) 2004 (1) 2003 (1) 1999 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent BJMBR Carvalho-Costa,P.G.; Branco,L.G.S.; Leite-Panissi,C.R.A.. Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical restraint-induced fever of rats can be blocked by inhibiting the enzyme HO. A previous study reported that the HO-CO-cGMP pathway plays a key phasic antinociceptive role in modulating noninflammatory acute pain. Thus, this study evaluated the involvement of the HO-CO-cGMP pathway in antinociception induced by acute stress in male Wistar rats (250-300 g; n=8/group) using the analgesia index (AI) in the tail flick test. The results showed that antinociception... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heme oxygenase; Carbon monoxide; CGMP; Lateral cerebral ventricle; Acute stress; Antinociception. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201057 Relationship between the actions of atrial natriuretic peptide (ANP), guanylin and uroguanylin on the isolated kidney BJMBR Santos-Neto,M.S.; Carvalho,A.F.; Forte,L.R.; Fonteles,M.C.. Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins. In the kidney, both of them have well-documented natriuretic and kaliuretic effects. Since atrial natriuretic peptide (ANP) also has a natriuretic effect mediated by cGMP, experiments were designed in the isolated perfused rat kidney to identify possible synergisms between ANP, guanylin and uroguanylin. Inulin was added to the perfusate and glomerular filtration rate (GFR) was determined at 10-min intervals. Sodium was also determined. Electrolyte dynamics were measured by the clearance formula. Guanylin (0.5 µg/ml, N = 12) or uroguanylin... Tipo: Info:eu-repo/semantics/article Palavras-chave: ANP; Guanylin; Uroguanylin; Kidney; Natriuresis; CGMP. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800012 4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP BJMBR Queiroz,R.N.; Ramos,E.R.P.; Alves-Do-Prado,W.. The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP. Since NO, cGMP and 4-aminopyridine alone induce tetanic fade and increase amplitude of muscular contractions in isolated rat neuromuscular preparations, the present study was undertaken to determine whether or not the neuromuscular effects of NO and 8-Br-cGMP can be modified by 4-aminopyridine. Using the phrenic nerve and diaphragm muscle isolated from male Wistar rats (200-250 g), we observed that L-arginine (4.7 mM) and 8-Br-cGMP (18 µM), in contrast to D-arginine, induced an increase in the amplitude of muscle... Tipo: Info:eu-repo/semantics/other Palavras-chave: L-arginine; Nitric oxide; CGMP; Skeletal muscle; Tetanic fade; K+ channel. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700016 Nitric oxide modulation of the hypothalamo-neurohypophyseal system BJMBR Kadekaro,M.. Nitric oxide (NO), a free radical gas produced endogenously from the amino acid L-arginine by NO synthase (NOS), has important functions in modulating vasopressin and oxytocin secretion from the hypothalamo-neurohypophyseal system. NO production is stimulated during increased functional activity of magnocellular neurons, in parallel with plastic changes of the supraoptic nucleus (SON) and paraventricular nucleus. Electrophysiological data recorded from the SON of hypothalamic slices indicate that NO inhibits firing of phasic and non-phasic neurons, while L-NAME, an NOS inhibitor, increases their activity. Results from measurement of neurohypophyseal hormones are more variable. Overall, however, it appears that NO, tonically produced in the forebrain,... Tipo: Info:eu-repo/semantics/article Palavras-chave: L-NAME; Vasopressin; Oxytocin; CGMP; ODQ; Microdialysis. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400001 Registros recuperados: 4 Primeira ... 1 ... Última

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