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| BERNAL,FABIÁN; HARTUNG,HANS-PETER; KIESEIER,BERND C. |
| Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent years, although current knowledge about their expression pattern in various tissues remains incomplete. Here we analyzed the relative mRNA expression of the most recently described MMPs _ MT5-MMP (MMP-24), MT6-MMP (MMP-25), MMP-27 and epilysin (MMP-28) _ in a broad selection of rat tissues using real time-PCR. MMP-24 mRNA was found to be widely expressed with predominance in the central nervous system. MMP-25 mRNA, in contrast, exhibited peak expression levels... |
| Tipo: Journal article |
Palavras-chave: Bone; CNS; Epilysin; Kidney; MT5-MMP; MT6-MMP; Testis. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200016 |
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| Saad,W.A.; Camargo,L.A.A.; Saad,R.; Pereira,A.F.; Simões,S.. |
| The drinking behavior responses to centrally administered NG-nitro-L-arginine methyl ester (L-NAME; 10, 20 or 40 µg/µl), an inhibitor of nitric oxide synthase, were studied in satiated rats, with cannulae stereotaxically implanted into the lateral ventricle (LV) and subfornical organ (SFO). Water intake increased in all animals after angiotensin II (ANG II) injection into the LV, with values of 14.2 ± 1.4 ml/h. After injection of L-NAME at doses of 10, 20 or 40 µg/µl into the SFO before injection of ANG II (12 ng/µl) into the LV, water intake decreased progressively and reached basal levels after treatment with 0.15 M NaCl and with the highest dose of L-NAME (i.e., 40 µg). The water intake obtained after 40 µg/µl L-NAME was 0.8 ± 0.01 ml/h. Also, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nitric oxide; Water intake; SFO; Dehydration; CNS. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100012 |
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| Buljubacich,Karina Alejandra; Mugnaini,María Teresa; Soñez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; Soñez,María Cristina; Gauna,Héctor Fernando. |
| The aim of this work was to determine the chronical stress effects on the encephalic NPY neurons population during the fetal Central nervous system development. Immunocytochemical techniques were used for this purpose: NPY neurons presented a similar morphology during the gestation days studied but their distribution varied in the anterior, medium and posterior brain. Statistical Highly significant differences in number of NPY positive neurons (p<0.01) among anterior, medium and posterior brain of stressed fetus (SF) were determined depending on the gestation period and the brain area. The NPY neurons were increased in ARC (Arcuate Hypothalamic Nucleus), PH (Posterior Hypothalamic Area) and DM (Dorsomedial Hypothalamic Nucleus) in stressed fetuses (SF)... |
| Tipo: Journal article |
Palavras-chave: NPY; Prenatal chronical stress; CNS; Rats. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300039 |
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