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	Provedor de dados BJMBR (1) Autor Prado,W.A. (1) Palavra-chave Analgesia (1) Antinociception (1) Calcium antagonists (1) Calcium ions (1) Opioids (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Involvement of calcium in pain and antinociception BJMBR Prado,W.A.. Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and antinociception, including the analgesic effects produced by opioids. The combination of opioids with drugs able to interfere with calcium ion functions in neurons has been pointed out as a useful alternative for safer clinical pain management. Alternatively, drugs that reduce the flux of calcium ions into neurons have been indicated as analgesic alternatives to opioids. This article reviews the manners by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antinociception; Analgesia; Calcium ions; Calcium antagonists; Opioids. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400003 Registros recuperados: 1 Primeira ... 1 ... Última

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