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Serum kinetics of Calloselasma rhodostoma (Malayan pit viper) venom components in a rabbit J. Venom. Anim. Toxins incl. Trop. Dis.
Tan,NH; Ponnudurai,G; Fung,SY.
The serum kinetics of Calloselasma rhodostoma (Malayan pit viper) venom - specifically two of its components, the major hemorrhagin (rhodostoxin) and a thrombin-like enzyme - was examined in a rabbit by double-sandwich enzyme-linked immunosorbent assay (ELISA). The animal received intramuscularly a 1.0-mg/kg dose of C. rhodostoma venom. The venom level in serum peaked 12 hours after the injection, followed by a gradual decline and finally reached low rates 72 hours after administration. The serum kinetic profile of venom components, however, did not correspond to the profile of the whole C. rhodostoma venom. The serum levels of the C. rhodostoma thrombin-like enzyme increased slowly and peaked only 48 hours post-injection. Then both thrombin-like enzyme...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Calloselasma rhodostoma venom; Thrombin-like enzyme; Hemorrhagin; Serum kinetics; Rabbit; ELISA.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200014
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