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	Provedor de dados BJM (1) Electron. J. Biotechnol. (1) Autor Al-Taweel,Areej M. (1) Al-Youssef,Hanan M. (1) Amina,Musarat (1) Amna,Touseef (1) Ligimol, (1) Madhusoodanan,P. V (1) Nishitha,I. K. (1) Poulose Martin,Kottackal (1) Puri,S.C. (1) Qazi,G. N. (1) Shahanaz Beegum,A (1) Sharma,P.R. (1) Slater,Adrian (1) Zhang,Chun-Lai (1) Mais... Palavra-chave Camptothecin (2) Cancer (1) Entrophospora infrequens (1) Medicinal plant (1) Nothapodytes foetida (1) Ophiorrhiza prostrata (1) Plant growth regulators (1) Precursors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2012 (1) 2007 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Organogenesis from leaf and internode explants of Ophiorrhiza prostrata, an anticancer drug (camptothecin) producing plant Electron. J. Biotechnol. Shahanaz Beegum,A; Poulose Martin,Kottackal; Zhang,Chun-Lai; Nishitha,I. K.; Ligimol,; Slater,Adrian; Madhusoodanan,P. V. Camptothecin (CPT) analogues and derivatives serve as a novel class of effective anticancer agents that exert their action against DNA topoisomerase I. This paper presents procedures for the rapid, high frequency regeneration of a camptothecin producing plant, Ophiorrhiza prostrata D. Don from leaf and internode explants via shoot organogenesis. The concentrations of plant growth regulators and explant types exhibited discrete roles in the efficacy of shoot induction. N6-benzyladenine (BA) was the most effective cytokinin for the induction of shoots. Murashige and Skoog (MS) medium with 8.87 µM BA and 2.46 µM indole-3-butyric acid (IBA) yielded the highest number of shoots from leaf and internode explants (76.0 and 90.8 shoots respectively). In the case of... Tipo: Journal article Palavras-chave: Camptothecin; Medicinal plant; Ophiorrhiza prostrata; Plant growth regulators. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000100011 Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus BJM Amna,Touseef; Amina,Musarat; Sharma,P.R.; Puri,S.C.; Al-Youssef,Hanan M.; Al-Taweel,Areej M.; Qazi,G. N.. We have established methodology for the isolation and characterization of a novel endophytic fungus from the inner bark of medicinal plant Nothapodytes foetida, which produced camptothecin in Sabouraud broth (SB) under shake flask conditions. Camptothecin and its related compounds are at present obtained by extraction from intact plants, but fungal endopytes may be an alternative source of production. In present study we have observed the effect of different nutrient combinations and precursors (tryptophan, tryptamine, geraniol, citral, mevalonic acid and leucine) on the accumulation of camptothecin by endophytic fungus Entrophospora infrequens. The precursors were fed either alone or in combinations (tryptophan and geraniol, tryptophan and citral,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Camptothecin; Entrophospora infrequens; Cancer; Nothapodytes foetida; Precursors. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400032 Registros recuperados: 2 Primeira ... 1 ... Última

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