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| Carvajal,Marcela; Espinoza,Luis; Caggia,Silvia; Cardile,Venera; Garbarino,Juan A; Peña-Cortés,Hugo; Russo,Alessandra. |
| Background: Several studies have shown that (-)-Jasmonic acid, (+)-7-iso-Jasmonic acid and its methyl ester, methyl jasmonate, have anti-cancer activity in vitro and in vivo, exhibiting selective cytotoxicity towards cancer cells. The degree of activity of these molecules is strongly related to their stereochemistry. The biotransformation of known compounds, natural or synthesized, related to interesting biological activities, generates new molecules displaying new improved properties compared with the original ones, increasing its value and providing new more effective products. Therefore, based on the above rationales and observations, in this work a biotransformation protocol to modify the chemical structure of the plant hormone jasmonic acid by using... |
| Tipo: Journal article |
Palavras-chave: Apoptosis; Biotransformations; Cancer cells; Cell vitality; Gibberella fujikuroi; Jasmonic acid. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000200007 |
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| Kong,Yanping; Zhang,Xianbo; Zhao,Yongliang; Xue,Yanfang; Zhang,Ye. |
| Abstract Background Cancer cells exhibit elevated levels of glucose uptake and may obtain pre-formed, diet-derived fatty acids from the bloodstream to boost their rapid growth; they may also use nucleic acid from their microenvironment. The study of processing nucleic acid by cancer cells will help improve the understanding of the metabolism of cancer. DNA is commonly packaged into a viral or lipid particle to be transferred into cells; this process is called transfection in laboratory. Cancer cells are known for having gene mutations and the evolving ability of endocytosis. Their uptake of DNAs might be different from normal cells; they may take in DNAs directly from the environment. In this report, we studied the uptake of DNAs in cancer cells without... |
| Tipo: Journal article |
Palavras-chave: DNA uptake; Cancer cells; Endocytosis. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100205 |
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| Rolim,P.M.; Fidelis,G.P.; Padilha,C.E.A.; Santos,E.S.; Rocha,H.A.O.; Macedo,G.R.. |
| Melon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted. Usually, inedible parts such as peel and seeds are discarded during processing and consumption. Extracts of melon residues were prepared and their phenolic compounds, antioxidants and antiproliferative activities were evaluated. Total phenolic compounds were found in hydroethanolic, hydromethanolic, and aqueous extracts, especially for melon peel (1.016 mg gallic acid equivalent/100 g). Flavonoids total content found for melon peel aqueous extract was 262 µg of catechin equivalent (CA)/100 g. In all extracts of melon peel significant amounts of gallic acid, catechin, and eugenol were found. For total antioxidant capacity,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Melon residues; Antioxidant activity; Cancer cells; Free radical scavenging activity; Metal chelator; Cytotoxicity. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400607 |
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