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Assessment of cell proliferation and prognostic factors in canine mammary gland tumors Arq. Bras. Med. Vet. Zootec.
Dutra,A.P.; Azevedo Júnior,G.M.; Schmitt,F.C.; Cassali,G.D..
Three methods for the analysis of cell proliferation, mitotic index/10 high-power fields (10 HPF), mitotic index/four sets of 10 HPF (40 HPF), and MIB-1 index were evaluated in a series of canine mammary gland tumors, as well as the possible correlation between them. Fifty-six canine mammary gland tumors, including 23 benign and 33 malignant, were studied. In addition, the prognostic impact of mitotic index/10 HPF, and histological malignancy grade were evaluated in 17 malignant tumors, being seven ductal and 10 metaplastic carcinomas. The three methods used to evaluate cell proliferation were correlated with the prognostic impact of mitotic index/10 HPF and histological malignancy grade. The results showed a strong association between mitotic figure...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine mammary tumors; MIB-1 index; Mitosis counting.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000600015
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c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors BJMBR
Dutra,A.P.; Granja,N.V.M.; Schmitt,F.C.; Cassali,G.D..
The objective of the present investigation was to study the expression of c-erbB-2 and MIB-1 and try to associate them with morphological features of the cell such as nuclear pleomorphism, mitotic count and histological grade in a series of 70 canine mammary gland tumors, 22 of them benign and 48 malignant. Tumors were collected at the Veterinary Hospital of UFMG (Brazil) and the Veterinary Faculty of Porto University (Portugal). c-erbB-2 expression was determined according to the guidelines provided by the manufacturer of the HercepTest system and nuclear pleomorphism, mitotic count and histological grade according the Elston and Ellis grading system. The HercepTest is the FDA-approved in vitro diagnostic test marketed by Dako. It is a semi-quantitative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine mammary tumors; Nuclear pleomorphism; Breast cancer; C-erbB-2 expression; MIB-1 expression.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100013
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Comments on the paper "c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors" BJMBR
Metze,K.; Adam,R.L..
Tipo: Info:eu-repo/semantics/other Palavras-chave: Canine mammary tumors; Nuclear pleomorphism; Statistical analysis; Scientific methods; C-erbB-2 expression; MIB-1 expression.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200001
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