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| Consiglieri,Vladi Olga; Mourão,Samanta; Sampaio,Mauricio; Granizo,Patricia; Garcia,Pedro; Martinello,Valeska; Spricigo,Rodrigo; Ferraz,Humberto Gomes. |
| The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluconazole/flowability; Tablets/dissolution; Capsules/dissolution; Plasdone. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100013 |
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| Enéas,Paula Cristina Rezende; Oliveira,Renata Barbosa de; Pianetti,Gerson Antônio. |
| Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. The formulations were also evaluated for parameters including drug-excipient compatibility, flowability, uniformity of weight, disintegration time, assay, uniformity of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxcarbazepine/quantitative analysis; Anticonvulsants/quantitative analysis; UV spectrophotometric/method validation; Capsules/dissolution. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200013 |
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