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| Assumpção,Paulo Pimentel de; Seabra,Aline Damasceno; Leal,Mariana Ferreira; Guimarães,Adriana Costa; Calcagno,Danielle Queiroz; Khayat,André Salim; Smith,Marilia de Arruda Cardoso; Burbano,Rommel Rodriguez. |
| In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumor cells that allows the increase of mutations is named genetic instability, encompassing two mechanisms: microsatellite instability, characterized by nucleotide alterations with errors in the DNA repair systems; and chromosomal instability, represented by aberrations occurring in large chromosome segments. Carcinomas are characterized by complex cytogenetic alterations and large gene amalgamations. Telomeric alterations, inadequately repaired DNA breaks, and... |
| Tipo: Journal article |
Palavras-chave: Chromosomal instability; Carcinomas; Aneuploidies. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400007 |
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| Varki,A.; Varki,N.M.. |
| Metastasis is a multistep cascade initiated when malignant cells penetrate the tissue surrounding the primary tumor and enter the bloodstream. Classic studies indicated that blood platelets form complexes around tumor cells in the circulation and facilitate metastases. In other work, the anticoagulant drug heparin diminished metastasis in murine models, as well is in preliminary human studies. However, attempts to follow up the latter observation using vitamin K antagonists failed, indicating that the primary mechanism of heparin action was unrelated to its anticoagulant properties. Other studies showed that the overexpression of sialylated fucosylated glycans in human carcinomas is associated with a poor prognosis. We have now brought all these... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heparin; Carcinomas; P-selectin; Mucin; Metastasis. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600003 |
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