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	Provedor de dados 47 (1) 58 (1) 60 (1) Autor Alvarez,María De Los Angeles (1) Bozic,Dragana D. (1) Cirkovic,Ivana (1) Debattista,Nora B. (1) Ferreira,Elizabeth Igne (1) Giarolla,Jeanine (1) Ivkovic,Branka (1) Milenkovic,Marina (1) Pappano,Nora B. (1) Pasqualoto,Kerly Fernanda Mesquita (1) Rando,Daniela Gonçalves (1) Zarelli,Valeria E. P. (1) Mais... Palavra-chave Chalcones (3) Antileishmanial agents (1) Bacteriostatic Activity (1) Biofilms (1) Chemometrics (1) Glycocalyx (1) Hydroxylation (1) Leishmaniasis (1) MRSA (1) N-acylhydrazones (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2014 (1) 2010 (1) 2004 (1) País Brazil (2) Argentina (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Bacteriostatic action of synthetic polyhydroxylated chalcones against Escherichia coli 47 Alvarez,María De Los Angeles; Zarelli,Valeria E. P.; Pappano,Nora B.; Debattista,Nora B.. In previous work the bacteriostatic action of trihydroxylated chalcones against Staphylococcus aureus ATCC 25 923 was investigated. In this work the action of 2´,4´,2-(OH)3-chalcone, 2´,4´,3-(OH)3- chalcone and 2´,4´,4-(OH)3 -chalcone against Escherichia coli ATCC 25 922 was evaluated. Growth kinetic curves of E.coli were made in nutritive broth added with increasing drug concentrations. The specific growth rates of the microorganisms were calculated by a kinetic turbidimetric method, which was previously probed and the minimal inhibitory concentrations (MIC´s) were evaluated by a mechanism of action proposed. The MICs of 2´,4´,3-(OH)3-chalcone and 2´,4´,2-(OH)3-chalcone were 46 mg/ml and 122 mg/ml, respectively. The 2´,4´,4-(OH)3-chalcone was inactive.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chalcones; Bacteriostatic Activity; Hydroxylation. Ano: 2004 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000100004 Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus 58 Bozic,Dragana D.; Milenkovic,Marina; Ivkovic,Branka; Cirkovic,Ivana. Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chalcones; Glycocalyx; Biofilms; MRSA. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100038 Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents 60 Rando,Daniela Gonçalves; Giarolla,Jeanine; Pasqualoto,Kerly Fernanda Mesquita; Ferreira,Elizabeth Igne. Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro assays. Since these chemical classes of compounds also resemble each other structurally, it would be useful to investigate whether they share direct analogy. Exploratory data analysis was applied to a library of chalcones and nitrated N-acylhydrazones assayed against Leishmania donovani to investigate their similarity. Under the conditions applied in the present study, the two classes did not present functional or structural analogy. Tipo: Info:eu-repo/semantics/article Palavras-chave: Chalcones; N-acylhydrazones; Antileishmanial agents; Leishmaniasis; Chemometrics. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200019 Registros recuperados: 3 Primeira ... 1 ... Última

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