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Cell death induced by tamoxifen in human blood lymphocytes cultivated in vitro - doi: 10.4025/actascibiolsci.v32i4.7015 Biological Sciences
Oliveira, Naila Francis Paulo de; UNICAMP; Genari, Selma Candelária; UNICAMP; Dolder, Heidi; UNICAMP.
Many chemotherapeutic agents with a potential against solid tumors or leukemia can cause lymphopenia. Tamoxifen (TAM) is a synthetic non-steroidal anti-estrogen drug employed in female breast cancer treatment. The present study investigated the capacity of TAM to induce cell death in human lymphocytes cultivated in vitro. Lymphocytes were obtained from young (25-30 years; n = 3) and elderly women (58-77 years; n = 3) and cultivated for 24 or 48h, with or without TAM (20 µM). After the culture, cell viability, immunocytochemical response and ultrastructure were evaluated. TAM affected lymphocytes in a time- dependent manner, and cells obtained from elderly women were the most sensitive to TAM. Immunocytochemical analysis evidenced higher frequency...
Palavras-chave: 2.06.01.00-0 Apoptosis; Autophagy; Chemotherapeutic; Cytotoxicity; Morphology; Ultrastructure Citologia e Biologia Celular.
Ano: 2010 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/7015
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Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate Arq. Bras. Med. Vet. Zootec.
Martins,D.B; Lopes,S.T.A; Mazzanti,C.M; Spanevello,R; Schmatz,R; Corrêa,M; Stefanello,N; Schetinger,M.R; Morsch,V; Veiga,A.P.M.
Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2 - vincristine sulphate (4mg/m²), G3 - physiologic solution, G4 - physiologic solution, G5- vincristine sulphate (4mg/m²), and G6 - vincristine sulphate (4mg/m²). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3 - nandrolone decanoate (1.8mg/kg-1), G4 - nandrolone decanoate (10mg/kg-1), G5 - nandrolone decanoate (1.8mg/kg-1), and G6 - nandrolone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat; Anabolic androgenic steroid; Chemotherapeutic; Free radicals; Brain; Blood serum.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017
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