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| Ribeiro,R.C.; Michalkiewicz,E.L.; Figueiredo,B.C.; DeLacerda,L.; Sandrini,F.; Pianovsky,M.D.; Sampaio,G.; Sandrini,R.. |
| Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer (p53 mutations) and selected genetic syndromes (Beckwith-Wiedemann syndrome) have been associated with childhood ACT in general but not with the Brazilian counterpart. Most of the affected children are young girls with classic endocrine syndromes (virilizing and/or Cushing). Levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (DHEA-S), which are abnormal in approximately 90% of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Adrenocortical adenoma; Adrenocortical carcinoma; Adrenal gland disorders; Pediatric cancers; Childhood adrenocortical tumors. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000013 |
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