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In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae) Acta Amazonica
SILVA,Nazaré Carneiro da; GONÇALVES,Suellen Ferreira; ARAÚJO,Luciana Silva de; KASPER,Aline Aparecida München; FONSECA,Amanda Luisa da; SARTORATTO,Adilson; CASTRO,Kelly Christina Ferreira; MORAES,Tânia Mara Pires; BARATTO,Leopoldo Clemente; VAROTTI,Fernando de Pilla; BARATA,Lauro Euclides Soares; MORAES,Waldiney Pires.
ABSTRACT Malaria is a disease of global tropical distribution, being endemic in more than 90 countries and responsible for about 212 million cases worldwide in 2016. To date, the strategies used to eradicate this disease have been ineffective, without specific preventive measures such as vaccines. Currently, the existing therapeutic arsenal is limited and has become ineffective against the expansion of artemisinin-resistant Plasmodium, demonstrating the need for studies that would allow the development of new compounds against this disease. In this context, we studied the volatile oil obtained from rhizomes of Cyperus articulatus (VOCA), a plant species commonly found in the Amazon region and popularly used as a therapeutic alternative for the treatment of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiplasmodial; Artemisinin resistance; Chloroquine resistance; Malaria; Plasmodium falciparum; Plasmodium berghei.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000400334
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Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru BJID
Llanos-Cuentas,A.; Campos,P.; Clendenes,M.; Canfield,C. J.; Hutchinson,D. B. A..
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15) or 1,500 mg chloroquine (base) over a 3 day period (n=14) (phase 1). The cure rate with chloroquine was lower than expected and patients were subsequently randomized to receive a single dose of 75 mg pyrimethamine and 1,500 mg sulfadoxine (n=9) or atovaquone/proguanil as before (n=5) (phase 2). In phase 1, atovaquone/proguanil was significantly more effective than chloroquine (cure rate 100% [14/14] versus 8%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malarone; Atovaquone; Proguanil; Chloroquine resistance; Peru.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200004
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