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	Provedor de dados BABT (1) Genet. Mol. Biol. (1) Phyton (1) Autor Amador,Rubem R. (1) Aydin,Elanur (1) Dórea,José G. (1) Lacava,Zulmira G. (1) Liu,DH (1) Longo,João Paulo Figueiró (1) Santos,Maria de Fátima M. Almeida (1) Turkez,Hasan (1) Wang,QL (1) Yue,JY (1) Mais... Palavra-chave Chromosome aberration (3) Allium cepa var. agrogarum L (1) Autophagy (1) Cadmium (Cd) (1) DNA damage (1) Metformin (1) Mutagenicity (1) Nucleolar organizing region (1) Nucleoli (1) Permethrin (1) Resveratrol (1) Sister chromatid exchange (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2016 (1) 2013 (1) 2012 (1) País Brazil (2) Argentina (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Metformin (dimethyl-biguanide) induced DNA damage in mammalian cells Genet. Mol. Biol. Amador,Rubem R.; Longo,João Paulo Figueiró; Lacava,Zulmira G.; Dórea,José G.; Santos,Maria de Fátima M. Almeida. Metformin (dimethyl-biguanide) is an insulin-sensitizing agent that lowers fasting plasma-insulin concentration, wherefore it's wide use for patients with a variety of insulin-resistant and prediabetic states, including impaired glucose tolerance. During pregnancy it is a further resource for reducing first-trimester pregnancy loss in women with the polycystic ovary syndrome. We tested metformin genotoxicity in cells of Chinese hamster ovary, CHO-K1 (chromosome aberrations; comet assays) and in mice (micronucleus assays). Concentrations of 114.4 µg/mL and 572 µg/mL were used in in vitro tests, and 95.4 mg/kg, 190.8 mg/kg and 333.9 mg/kg in assaying. Although the in vitro tests revealed no chromosome aberrations in metaphase cells, DNA damage was detected... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metformin; DNA damage; Chromosome aberration. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100022 The uptake of cadmium by Allium cepa var. agrogarum L. and its effects on chromosome and nucleolar behavior in root tip cells Phyton Wang,QL; Liu,DH; Yue,JY. Allium cepa var. agrogarum L. seedlings are sensitive to Cd stress. We used fluorescence imaging to indicate that Cd2+ was localized in cytoplasm in the epidermis of the basal parts of root and vascular tissues after Cd treatment. The nucleoli and the cell walls were the first storage sites of Cd2+. When Cd exposure was prolonged, severe irregularly-shaped nuclei were induced. We used silver nitrate staining to analyze the effects of different concentrations (1-300 µM) of cadmium chloride on chromosome, nucleolus and nucleolus organizer regions (NORs) in root tip cells. Cd2+ induced c-mitosis, chromosome bridges, chromosome stickiness and micronuclei. More than 100 µM Cd2+ could induce nucleolar material extruded from the nucleus into the cytoplasm. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cadmium (Cd); Allium cepa var. agrogarum L; Chromosome aberration; Nucleoli; Nucleolar organizing region; Autophagy. Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572016000100021 The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes BABT Turkez,Hasan; Aydin,Elanur. The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chromosome aberration; Mutagenicity; Permethrin; Resveratrol; Sister chromatid exchange. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008 Registros recuperados: 3 Primeira ... 1 ... Última

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