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	Provedor de dados Anais da ABC (AABC) (1) Genet. Mol. Biol. (1) Autor Bizari,Lucimari (1) Serov,Oleg (1) Serova,Irina (1) Silva,Ana Elizabete (1) Tajara,Eloiza Helena (1) Palavra-chave Chromosome territories (2) CCND1 (1) Developmental genes (1) Epigenetic regulation (1) Esophageal carcinoma (1) Gastric cancer (1) Genetic networks (1) HER-2/neu (1) Organization of the interphase nucleus (1) Variegated position effect (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Peripheral position of CCND1 and HER-2/neu oncogenes within chromosome territories in esophageal and gastric cancers non-related to amplification and overexpression Genet. Mol. Biol. Bizari,Lucimari; Tajara,Eloiza Helena; Silva,Ana Elizabete. Interphase chromosomes have been shown to occupy discrete regions of the nucleus denominated chromosome territories (CTs), their active genes being preferentially positioned on the surfaces of these CTs, where they are accessible to transcriptional machinery. By means of FISH (Fluorescence in situ Hybridization), we analyzed the CCND1 and HER-2/neu gene positions within the CTs and their relationship with gene amplification and protein over-expression in esophageal and gastric cancers. The CCND1 and HER-2/Neu genes were more often positioned at the periphery (mean frequency of 60%-83%) of the CTs in tumor tissues of the esophagus and stomach. Moreover, this positioning revealed no association with either gene amplification or the protein over-expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCND1; HER-2/neu; Chromosome territories; Esophageal carcinoma; Gastric cancer. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200006 Genes and chromosomes: control of development Anais da ABC (AABC) Serov,Oleg; Serova,Irina. The past decade has witnessed immense progress in research into the molecular basis behind the developmental regulation of genes. Sets of genes functioning under hierarchical control have been identified, evolutionary conserved systems of genes effecting the cell-to-cell transmission of transmembrane signals and assigned a central role in morphogenesis have been intensively studied; the concept of genomic regulatory networks coordinating expression of many genes has been introduced, to mention some of the major breakthroughs. It should be noted that the temporal and tissue-specific parameters of gene expression are correctly regulated in development only in the context of the chromosome and that they are to a great extent dependent on the position of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Epigenetic regulation; Developmental genes; Genetic networks; Variegated position effect; Chromosome territories; Organization of the interphase nucleus. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300007 Registros recuperados: 2 Primeira ... 1 ... Última

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