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Acetylcholinesterase activity in the pons and medulla oblongata of rats after chronic electroconvulsive shock BJMBR
Camarini,R.; Benedito,M.A.C..
An imbalance between cholinergic and noradrenergic neurotransmission has been proposed for the etiology of affective disorders. According to this hypothesis, depression would be the result of enhanced cholinergic and reduced noradrenergic neurotransmission. Repeated electroconvulsive shock (ECS) is an effective treatment for depression; moreover, in laboratory animals it induces changes in brain noradrenergic neurotransmission similar to those obtained by chronic treatment with antidepressant drugs (down-regulation of beta-adrenergic receptors). The aim of the present study was to determine whether repeated ECS in rats changes acetylcholinesterase (Achase) activity. Achase controls the level of acetylcholine (Ach) in the synaptic cleft and its levels seem...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase; Medulla oblongata; Pons; Chronic electroconvulsive shock.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000012
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