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Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats BJMBR
Estato,V.; Araújo,C.V.; Bousquet,P.; Tibiriçá,E..
We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nervous system, were compared to those of dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H -pyrrol-2-yl)-amine hydrochloride (LNP 509), which selectively binds to the I1BS. Terminal mesenteric arterioles were observed by intravital microscopy. Activation of the central sympathetic system with L-glutamate (125 µg, ic) induced marked vasoconstriction of the mesenteric microcirculation (27 ± 3%; N = 6, P <...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesenteric microcirculation; Arterial hypertension; Clonidine; Rilmenidine; Baclofen; LNP 509.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000014
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Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I BJMBR
Nascimento,M.S.A.; Klamt,J.G.; Prado,W.A..
Sympathetic ganglion block (SGB) or intravenous regional block (IVRB) has been recommended for pain management in patients with complex regional pain syndrome type I (CRPS-I). Forty-five patients were initially selected but only 43 were accepted for the study. The present study evaluated the efficacy of IVRB produced by combining 70 mg lidocaine with 30 µg clonidine (14 patients, 1 male/13 females, age range: 27-50 years) versus SGB produced by the injection of 70 mg lidocaine alone (14 patients, 1 male/13 females, age range: 27-54 years) or combined with 30 µg clonidine (15 patients, 1 male/14 females, age range: 25-50 years) into the stellate ganglion for pain management in patients with upper extremity CRPS-I. Each procedure was repeated five times at...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clonidine; Complex regional pain syndrome type I; Intravenous regional block; Lidocaine; Stellate ganglion block; Sympathetic ganglion block.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200014
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