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| van der Spuy,Wendy Jeannette; Pretorius,Etheresia. |
| Dysferlinopathy is a form of muscular dystrophy affecting muscles of the shoulder and pelvic girdles, resulting from inheritance of a mutated dysferlin gene. The encoded dysferlin protein is proposed to be involved in sarcolemmal vesicle fusion with a disrupted plasma membrane; however, with defective protein function these vesicles accumulate beneath the disruption site but are unable to fuse with it and reseal the membrane, thus rendering the membrane repair mechanism defective. The SJL/J mouse model presents with characteristics much like the commonest human condition. Immune modulators have long been under study in the maintenance of muscle health in muscular dystrophies. Such supplementary treatment would ideally suppress inflammation, preventing the... |
| Tipo: Journal article |
Palavras-chave: Dysferlinopathy; Coenzyme Q10; Resveratrol; Sarcolemma. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300035 |
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| Asadi,H; Sadeghi,AA; Eila,N; Aminafshar,M. |
| ABSTRACT This study was conducted to evaluate the effects of coenzyme Q10, L-carnitine and ractopamine supplementation, alone and in combinations, on carcass traits and immune response of broiler chickens. Five hundred and twelve one-day-old Ross 308 male broiler chickens were randomly allocated into eight treatments with four replicates each. A 2×2×2 factorial arrangement was applied, with two levels of coenzyme Q10 (0 and 40 mg/kg), two levels of L-carnitine (0 and 200 mg/kg) and two levels of ractopamine (0 and 10 mg/kg). The birds were reared until day 42 of age under standard conditions. Blood samples were collected at the end of grower and finisher periods from the wing vein. Four birds per group were sacrificed at day 42 of age. Except for carcass... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coenzyme Q10; L-carnitine; Ractopamine; Broiler chicken. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2016000400677 |
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| Nemati,MH; Shahir,MH; Harakinezhad,MT; Lotfalhian,H. |
| ABSTRACT We hypothesized that the supplementation of vitamin C (Vit. C) and coenzyme Q10 (CoQ10) alone or in combination could reduce the negative effects of cold stress in broilers. Four hundred male chicks were exposed for 24 h to cold stress (15 ºC) starting from 15d of age, while a positive control group (PC, 100 birds) was kept under normal temperature condition. The experimental groups under cold stress (four treatments in 5 replicates of 20 birds) were: negative control (NC, basal diet), Vit. C (basal diet + 300 mg/kg Vit. C), CoQ10 (basal diet + 40 mg/kg CoQ10) and Vit. C plus CoQ10 (basal diet + Vit. C+ CoQ10at above mentioned doses). Vit. C or CoQ10 supplementation were restored (p<0.01) performance and lowered (p<0.01) ascites mortality.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ascites; Broiler; Coenzyme Q10; Cold stress; Vitamin C. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000300537 |
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| Santos,Graciela Cristina dos; Antunes,Lusânia Maria Greggi; Santos,Antonio Cardozo dos; Bianchi,Maria de Lourdes Pires. |
| According to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number of neurodegenerative diseases. These diseases include common and debilitating disorders, characterized by progressive and irreversible loss of neurons in specific regions of the brain. The most common neurodegenerative diseases are Parkinson's disease, Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Coenzyme Q10 (CoQ10) has been extensively studied since its discovery in 1957. It is a component of the electron transportation chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). The property of CoQ10 to act as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coenzyme Q10; Antioxidant; Oxidative stress; Neurodegenerative diseases. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400002 |
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