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| Ada,Ahmet Oguz; Yilmazer,Meltem; Suzen,Sinan; Demiroglu,Canan; Demirbag,Ali Eba; Efe,Sibel; Alemdar,Yavuz; Burgaz,Sema; Iscan,Mumtaz. |
| Genetic polymorphisms of xenobiotic metabolizing enzymes have been associated with cancer risk. We evaluated the influences of genetic polymorphisms of polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes on urinary 1-hydroxypyrene (1-OHP) excretion in Turkish coke oven workers. Urinary 1-OHP was analyzed by HPLC after enzymatic hydrolysis. Lymphocyte DNA was used for PCR-based genotyping of cytochrome P450 (CYP) polymorphisms (CYP1A1 and CYP1B1) and glutathione S-transferases (GST) polymorphisms (GSTM1, GSTT1 and GSTP1). The mean urinary 1-OHP levels of coke oven workers were significantly higher than that of controls. No significant difference was detected in the mean urinary 1-OHP levels of smokers and non-smokers either for coke oven workers or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polycyclic aromatic hydrocarbons; 1-hydroxypyrene; Coke oven workers; Cytochrome P450s; Glutathione S-transferases. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400002 |
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