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	Provedor de dados BJMBR (2) Autor Aprilli,F. (1) Cunha,F.Q. (1) Escalante,R.D. (1) Garcia,S.B. (1) Montenegro,M.R. (1) Ribeiro-Silva,A. (1) Rodrigues,M.A.M. (1) Salvadori,D.M.F. (1) Silva,L.A.G. (1) Vespúcio,M.V.O. (1) de Camargo,J.L.V. (1) de Oliveira,Ê.C. (1) Mais... Palavra-chave Colon carcinogenesis (2) Aberrant crypt foci (1) Dimethylhydrazine (1) Metallothioneins (1) Nimesulide (1) Preneoplastic lesion (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2006 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis BJMBR Escalante,R.D.; de Oliveira,Ê.C.; Cunha,F.Q.; Vespúcio,M.V.O.; Ribeiro-Silva,A.; Aprilli,F.; Garcia,S.B.. Trypanosoma cruzi infection and nonsteroidal anti-inflammatory drugs inhibit colorectal carcinogenesis by mechanisms not completely known and metallothionein proteins (MTs) may be involved in this process. Sixty-six male Wistar rats weighing 90 to 120 g were randomly divided into seven groups (GI to GVII). GI, GII and GIII animals were subcutaneously infected with 200,000 trypomastigote forms of the Y strain of T. cruzi. After 8 weeks, GI, GII, GIV, and GVI were injected with one weekly subcutaneous dose of 12 mg/kg dimethylhydrazine for 4 weeks. In sequence, GI, GIV and GV were treated with nimesulide (10 mg/kg per dose, five times per week for 8 weeks). Groups I, III, IV, and VI had 12 animals, and each of the other groups had 6 animals. All the animals... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Nimesulide; Dimethylhydrazine; Metallothioneins; Colon carcinogenesis. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000700007 Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats BJMBR Rodrigues,M.A.M.; Silva,L.A.G.; Salvadori,D.M.F.; de Camargo,J.L.V.; Montenegro,M.R.. Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be the earliest hallmark of colon carcinogenesis. In the present study the relationship between a short-term (4 weeks) and medium-term (30 weeks) assay was assessed in a model of colon carcinogenesis induced by dimethylhydrazine (DMH) in the rat. Six-week-old male Wistar rats were given subcutaneous injections of DMH (40 mg/kg) twice a week for 2 weeks and killed at the end of the 4th or 30th week. ACF were scored for number, distribution pattern along the colon and crypt multiplicity in 0.1% methylene-blue whole-mount preparations. ACF were distinguished from normal crypts by their larger size and elliptical shape. The incidence, distribution and morphology of colon... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aberrant crypt foci; Preneoplastic lesion; Colon carcinogenesis. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300010 Registros recuperados: 2 Primeira ... 1 ... Última

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