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	Provedor de dados BABT (1) Autor Amaral,Ademir (1) Cavalcanti,Mariana Brayner (1) Machado,Cíntia Gonsalves de Faria (1) Neves,Maria Amélia Batista (1) Santos,Neyliane Gonçalves dos (1) Palavra-chave Combined therapy (1) Flow cytometry (1) Functional analysis (1) Multidrug resistance (1) P-glycoprotein (1) Radiation effect (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2008 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Flow cytometry protocol to evaluate ionizing radiation effects on P-glycoprotein activity BABT Santos,Neyliane Gonçalves dos; Amaral,Ademir; Cavalcanti,Mariana Brayner; Neves,Maria Amélia Batista; Machado,Cíntia Gonsalves de Faria. The aim of this work was to establish a protocol to evaluate ionizing radiation effects on P-glycoprotein (P-gp) activity. For this, human peripheral blood samples were irradiated in vitro with different doses and P-gp activity was analyzed for CD4 and CD8 T lymphocytes through rhodamine123-efflux assay by flow cytometry. By simultaneous employment of percentage and mean fluorescence index parameters, subject-by-subject analysis pointed out changes in P-gp activity for some individuals and irradiated samples. Based on this work, the proposed protocol was considered adequate for evaluating P-gp activity on cells after radioactive stress. Besides, this research suggests that P-gp activity could be an important factor to define patient-specific protocols in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Combined therapy; Radiation effect; P-glycoprotein; Multidrug resistance; Functional analysis; Flow cytometry. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700018 Registros recuperados: 1 Primeira ... 1 ... Última

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